Hogg J C
University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, Canada.
AJR Am J Roentgenol. 1991 Feb;156(2):225-33. doi: 10.2214/ajr.156.2.1898791.
Chronic interstitial lung disease of unknown cause is usually classified on the basis of descriptive histology. In this lecture, a recently published series of 910 cases of chronic interstitial lung disease is used to show that these descriptive terms can be reorganized into a classification that is based on inflammatory and neoplastic processes. The proposed classification includes three major diagnostic categories, two of which are based on the chronic inflammatory response and a third that results from infiltration of the interstitial space by neoplastic cells of either a benign, borderline, or frankly malignant nature. An argument is presented that the steps involved in the development of the endstage of chronic interstitial lung disease are similar in all three groups. The advantage of this new classification is that it shifts the emphasis from descriptive terminology to pathogenesis, which provides a more critical basis for investigation of the causes of these diseases.
病因不明的慢性间质性肺病通常根据描述性组织学进行分类。在本次讲座中，最近发表的一系列910例慢性间质性肺病病例被用来表明，这些描述性术语可以重新组织成一种基于炎症和肿瘤过程的分类。所提出的分类包括三个主要诊断类别，其中两个基于慢性炎症反应，第三个则是由良性、临界性或明显恶性性质的肿瘤细胞浸润间质空间所致。有人认为，这三组疾病中慢性间质性肺病终末期发展所涉及的步骤是相似的。这种新分类的优点在于，它将重点从描述性术语转移到发病机制上，这为研究这些疾病的病因提供了更关键的基础。
