Ashikari R, Huvos A G, Snyder R E
Cancer. 1977 Feb;39(2):435-9. doi: 10.1002/1097-0142(197702)39:2<435::aid-cncr2820390211>3.0.co;2-w.
A long-term prospective study of non-infiltrating breast carcinoma is being carried out in order to study the natural history and proper management of such lesions with particular interest in patients treated solely by local excision. During an 11-year period, 175 patients with lobular Ca in situ and intraductal Ca have been followed. None has developed recurrent disease including 18 undergoing wide local excision only. Histologic examination revealed that 36% of mastectomy specimens showed multifocal lesions, whereas only one of the patients treated by wide local excision had more than one microscopic focus. For these reasons total mastectomy is recommended as the treatment of non-infiltrating breast carcinoma. Subsequent development of contralateral cancer has occurred in ten patients.
正在进行一项关于非浸润性乳腺癌的长期前瞻性研究，以研究此类病变的自然病史和恰当治疗方法，尤其关注仅接受局部切除治疗的患者。在11年期间，对175例小叶原位癌和导管内癌患者进行了随访。无一例发生复发性疾病，其中18例仅接受了广泛局部切除。组织学检查显示，36%的乳房切除标本呈现多灶性病变，而在接受广泛局部切除治疗的患者中，只有1例有一个以上的显微镜下病灶。基于这些原因，建议将全乳切除术作为非浸润性乳腺癌的治疗方法。有10例患者随后发生了对侧癌。
