Kumaratilake L M, Ferrante A, Rzepczyk C
Department of Immunology, Adelaide Children's Hospital, South Australia.
J Immunol. 1991 Jan 15;146(2):762-7.
Human neutrophils were treated with IFN-gamma or lymphotoxin and their interaction with the asexual blood forms of Plasmodium falciparum was studied by a radiometric assay and microscopy. The results showed that human neutrophils inhibited the growth of P. falciparum and killed the parasite via a phagocytic mechanism. The cytokines significantly augmented the neutrophil-mediated killing of the parasite. When compared with the effects of TNF-alpha similar results were seen although IFN-gamma and TNF-alpha were effective at 10-fold less the concentration of lymphotoxin. The maximum neutrophil-mediated parasite killing was seen in the presence of immune serum and the cytokines. These findings suggest that T cells regulate the antimalarial activity of neutrophils.
用人γ-干扰素或淋巴毒素处理人中性粒细胞，并通过放射性测定法和显微镜观察研究它们与恶性疟原虫无性血液期形态的相互作用。结果表明，人中性粒细胞可抑制恶性疟原虫的生长，并通过吞噬机制杀死该寄生虫。细胞因子显著增强了中性粒细胞介导的对寄生虫的杀伤作用。与肿瘤坏死因子-α的作用相比，尽管γ-干扰素和肿瘤坏死因子-α在浓度比淋巴毒素低10倍时仍有效，但仍观察到类似结果。在存在免疫血清和细胞因子的情况下，可见到中性粒细胞介导的对寄生虫的最大杀伤作用。这些发现提示T细胞调节中性粒细胞的抗疟活性。
