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1型人类免疫缺陷病毒（HIV-1）感染及未感染人群血清中HIV-1抗p24反应性的差异：免疫印迹不确定反应分析

Differences in human immunodeficiency virus type 1 (HIV-1) anti-p24 reactivities in serum of HIV-1-infected and uninfected subjects: analysis of indeterminate western blot reactions.

作者信息

Povolotsky J, Gold J W, Chein N, Baron P, Armstrong D

机构信息

Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

出版信息

J Infect Dis. 1991 Feb;163(2):247-51. doi: 10.1093/infdis/163.2.247.

DOI:10.1093/infdis/163.2.247
PMID:1899100
Abstract

Anti-p24 reactions in sera from 42 human immunodeficiency virus type 1 (HIV-1)-infected and 36 uninfected people with indeterminate Western blot antibody tests for HIV-1 were studied. Anti-p24 reactivity in HIV-1-infected people was completely blocked by HIV-1 recombinant p24 antigen, whereas the reaction in uninfected individuals with indeterminate patterns was inhibited partly or not at all. In contrast to infected individuals, anti-p24 reactivity from uninfected individuals could not be detected by an inhibition ELISA for HIV-1 p24 antibody. These results suggest a practical way to distinguish anti-p24 reactivity in sera from patients with HIV-1 infection from that seen in uninfected patients with indeterminate Western blot reactions.

摘要

对42名感染人类免疫缺陷病毒1型（HIV-1）的患者以及36名HIV-1免疫印迹抗体检测结果不确定的未感染个体的血清中的抗p24反应进行了研究。HIV-1感染患者血清中的抗p24反应性被HIV-1重组p24抗原完全阻断，而免疫印迹结果不确定的未感染个体的反应仅被部分抑制或未被抑制。与感染个体不同，未感染个体的抗p24反应性无法通过HIV-1 p24抗体抑制ELISA检测到。这些结果提示了一种实用的方法，可区分HIV-1感染患者血清中的抗p24反应性与免疫印迹反应不确定的未感染患者血清中的抗p24反应性。

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