Alters S E, Shizuru J A, Ackerman J, Grossman D, Seydel K B, Fathman C G
Department of Medicine, Stanford University School of Medicine, California 94305.
J Exp Med. 1991 Feb 1;173(2):491-4. doi: 10.1084/jem.173.2.491.
Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.
使用抗CD4单克隆抗体消耗CD4+细胞可导致同种异体移植耐受。我们在此表明,在没有对潜在的IE反应性Vβ11+ T细胞进行克隆清除的情况下,抗CD4介导的对从A/J(IEk)供体移植到糖尿病C57B1/6(B6)(IE-)受体的胰岛朗汉斯细胞的耐受得以发生。相反,在CD4+Vβ11+和CD8+Vβ11+ T细胞亚群中均诱导出克隆无能状态。通过添加重组白细胞介素2,这种克隆无能在体外可部分被克服。