Chen Yi-Lei, Tan Chang-Heng, Tan Jun-Jie, Qu Shi-Jin, Jiang Shan-Hao, Zhu Da-Yuan
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai, P. R. China.
Planta Med. 2008 Dec;74(15):1826-8. doi: 10.1055/s-0028-1088328. Epub 2008 Nov 7.
Callianthones A ( 1) and B ( 2), a pair of new isomeric alpha-tetralones, together with a known alpha-tetralone ( 3) and four known flavonoids ( 4 - 7) were isolated from the 50 % EtOH extract of Pyrola calliantha. The structures and absolute configurations of the two new isomers were established to be (2 S,4 R) - and (2 S,4 S)-2,4-dihydroxy-2,7-dimethyl-3,4-dihydronaphthalen-1(2 H)-one ( 1 and 2, respectively) on the basis of spectral analysis, including 2 D NMR, model studies, and CD spectra.
从鹿蹄草的50%乙醇提取物中分离得到了一对新的异构体α-四氢萘酮，即Callianthones A（1）和B（2），以及一个已知的α-四氢萘酮（3）和四种已知的黄酮类化合物（4 - 7）。基于包括二维核磁共振、模型研究和圆二色光谱在内的光谱分析，确定这两种新异构体的结构和绝对构型分别为(2S,4R)-和(2S,4S)-2,4-二羟基-2,7-二甲基-3,4-二氢萘-1(2H)-酮（分别为1和2）。
