Machida Koichi, Matsuoka Erika, Kasahara Takayuki, Kikuchi Masao
Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan.
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):934-7. doi: 10.1248/cpb.53.934.
Four enantiomerically pure new alpha-tetralones, (4S)- and (4R)-5-hydroxy-4-methoxy-alpha-tetralones and (4S)- and (4R)-5,8-dihydroxy-4-methoxy-alpha-tetralones were isolated, together with five known ones, (4S)- and (4R)-4,8-dihydroxy-alpha-tetralones, (4S)-4,8-dihydroxy-5-methoxy-alpha-tetralone and (4S)- and (4R)-4-hydroxy-alpha-tetralones, from the fruit of Juglans mandshurica MAXIM. var. sieboldiana MAKINO. Their structures were established on the basis of spectral analysis. To the best of our knowledge, this is the first isolation of the (4R)-4-hydroxy-alpha-tetralone derivative from Juglans species.
从胡桃楸变种野核桃（Juglans mandshurica MAXIM. var. sieboldiana MAKINO）的果实中分离出了四种对映体纯的新型α-四氢萘酮，即(4S)-和(4R)-5-羟基-4-甲氧基-α-四氢萘酮以及(4S)-和(4R)-5,8-二羟基-4-甲氧基-α-四氢萘酮，同时还分离出了五种已知的化合物，即(4S)-和(4R)-4,8-二羟基-α-四氢萘酮、(4S)-4,8-二羟基-5-甲氧基-α-四氢萘酮以及(4S)-和(4R)-4-羟基-α-四氢萘酮。它们的结构通过光谱分析得以确定。据我们所知，这是首次从胡桃属植物中分离出(4R)-4-羟基-α-四氢萘酮衍生物。
