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Biologically active tetralones from New Caledonian Zygogynum spp.

作者信息

Allouche Noureddine, Morleo Barbara, Thoison Odile, Dumontet Vincent, Nosjean Olivier, Guéritte Françoise, Sévenet Thierry, Litaudon Marc

机构信息

Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.

出版信息

Phytochemistry. 2008 May;69(8):1750-5. doi: 10.1016/j.phytochem.2008.01.025. Epub 2008 Mar 10.

DOI:10.1016/j.phytochem.2008.01.025
PMID:18334258
Abstract

Bioassay guided purification of the ethyl acetate extracts of the bark and leaves of five New Caledonian Zygogynum species (Winteraceae) led to the isolation and characterization of four phenyl-3-tetralones (3,4-dihydronaphthalen-1(2H)-one). Their structures were determined by various NMR techniques and chemical studies. The absolute configuration of the compounds was established by circular dichroism. The compounds showed binding affinity for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and significant inhibitory activity against KB cancer cell line.

摘要

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