Murray Martha M, Palmer Matthew, Abreu Eduardo, Spindler Kurt P, Zurakowski David, Fleming Braden C
Department of Orthopaedic Surgery, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
J Orthop Res. 2009 May;27(5):639-45. doi: 10.1002/jor.20796.
In this study, we hypothesize that supplementation of suture repair of the anterior cruciate ligament (ACL) with platelet-rich plasma (PRP) will improve the biomechanics of the repair. Six 30-kg pigs underwent bilateral suture repair of the ACL. One side was treated with suture repair alone, while the contralateral side was treated with suture repair augmented with PRP. After 14 weeks in vivo, anterior-posterior (AP) knee laxity and the tensile properties of the repaired ligament were measured. The addition of PRP to the suture repairs did not improve AP knee laxity at 30 degrees (p = 0.73) or 60 degrees (p = 0.65). It also did not improve the maximum tensile load (p = 0.64) or linear stiffness (p = 0.42) of the ACL repairs after 14 weeks in vivo. The model had 80% power to detect a 30% improvement of biomechanical properties with PRP; thus, we are confident that a clinically meaningful effect as a result of adding PRP is unlikely. Use of PRP alone to supplement suture repair of the ACL is ineffective in this animal model.
在本研究中，我们假设用富血小板血浆（PRP）补充前交叉韧带（ACL）的缝合修复将改善修复的生物力学性能。六只30千克重的猪接受了双侧ACL缝合修复。一侧仅采用缝合修复治疗，而对侧采用PRP增强的缝合修复治疗。体内14周后，测量膝关节前后（AP）松弛度和修复韧带的拉伸性能。在缝合修复中添加PRP在30度（p = 0.73）或60度（p = 0.65）时并未改善AP膝关节松弛度。在体内14周后，它也未改善ACL修复的最大拉伸负荷（p = 0.64）或线性刚度（p = 0.42）。该模型有80%的把握检测到PRP使生物力学性能提高30%；因此，我们确信添加PRP不太可能产生具有临床意义的效果。在该动物模型中，单独使用PRP补充ACL缝合修复是无效的。
