• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

抗衰老疗法的科学方法:当前进展

A scientific approach to anti-ageing therapies: state of the art.

作者信息

Jirillo E, Candore G, Magrone T, Caruso C

机构信息

Immunology, University of Bari, Bari, Italy.

出版信息

Curr Pharm Des. 2008;14(26):2637-42. doi: 10.2174/138161208786264070.

DOI:10.2174/138161208786264070
PMID:18991682
Abstract

A lasting dream of human beings is to reverse or at least postpone ageing. During the last years, an increasing number of scientific meetings, articles, and books have been devoted to anti-ageing therapies. This subject, full of misleading, simplistic, or wrong ideas, is very popular among the general public, whose imagery has been fascinated by all possible tools to delay ageing, getting immortality. Here, we discuss anti-ageing strategies aimed not to rejuvenate but to slow ageing and delay the onset of age-related diseases. These approaches should be able to substantially slow down the ageing process, extending our productive, youthful lives.

摘要

人类长久以来的梦想是逆转衰老,或者至少延缓衰老。在过去几年里,越来越多的科学会议、文章和书籍都致力于抗衰老疗法。这个充满误导性、过于简单或错误观念的主题在普通大众中非常受欢迎,大众的想象被所有可能延缓衰老、实现永生的工具所吸引。在此,我们讨论的抗衰老策略并非旨在让人返老还童,而是减缓衰老并推迟与年龄相关疾病的发生。这些方法应能够大幅减缓衰老过程,延长我们富有活力的青春岁月。

相似文献

1
A scientific approach to anti-ageing therapies: state of the art.抗衰老疗法的科学方法:当前进展
Curr Pharm Des. 2008;14(26):2637-42. doi: 10.2174/138161208786264070.
2
Nutrient sensing pathways as therapeutic targets for healthy ageing.营养感应通路作为健康衰老的治疗靶点。
Expert Opin Ther Targets. 2017 Apr;21(4):371-380. doi: 10.1080/14728222.2017.1294684. Epub 2017 Feb 17.
3
Rationale and methods of discovering hormetins as drugs for healthy ageing.发现作为健康衰老药物的 hormetins 的原理和方法。
Expert Opin Drug Discov. 2012 May;7(5):439-48. doi: 10.1517/17460441.2012.677430. Epub 2012 Apr 17.
4
The promise of slow down ageing may come from curcumin.姜黄素可能带来延缓衰老的希望。
Curr Pharm Des. 2010;16(7):884-92. doi: 10.2174/138161210790883507.
5
A new anti-ageing strategy focused on prevention of arterial ageing in the middle-aged population.一种新的抗衰老策略,专注于预防中年人群的动脉老化。
Med Hypotheses. 2013 Jun;80(6):837-40. doi: 10.1016/j.mehy.2013.03.028. Epub 2013 Apr 12.
6
Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement.低度炎症作为与年龄相关疾病的共同发病机制:抗衰老策略和成功老龄化实现的新药物靶点。
Curr Pharm Des. 2010;16(6):584-96. doi: 10.2174/138161210790883868.
7
Human ageing as a dynamic, emergent and malleable process: from disease-oriented to health-oriented approaches.人类衰老作为一个动态、涌现和可塑的过程:从以疾病为导向到以健康为导向的方法。
Biogerontology. 2020 Feb;21(1):125-130. doi: 10.1007/s10522-019-09839-w. Epub 2019 Oct 8.
8
[Anti-ageing therapies in Alzheimer's disease].[阿尔茨海默病的抗衰老疗法]
Rev Esp Geriatr Gerontol. 2018 Jan-Feb;53(1):45-53. doi: 10.1016/j.regg.2017.02.007. Epub 2017 May 24.
9
Brief Challenges on Medicinal Plants: An Eye-Opening Look at Ageing-Related Disorders.药用植物简述:衰老相关疾病的新视角。
Basic Clin Pharmacol Toxicol. 2018 Jun;122(6):539-558. doi: 10.1111/bcpt.12972. Epub 2018 Mar 25.
10
Synthetic drugs with anti-ageing effects.具有抗衰老作用的合成药物。
Drug Discov Today. 2009 Sep;14(17-18):899-904. doi: 10.1016/j.drudis.2009.07.006. Epub 2009 Jul 26.

引用本文的文献

1
Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis.年龄相关性子宫变化及其与不良生殖结局的关系:系统评价和荟萃分析。
Reprod Biol Endocrinol. 2024 Nov 30;22(1):152. doi: 10.1186/s12958-024-01323-6.
2
A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly.老年人炎症与认知关系背后机制的综述及假设模型
Front Aging Neurosci. 2019 Mar 13;11:56. doi: 10.3389/fnagi.2019.00056. eCollection 2019.
3
Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies.
松萝提取物通过改善Aβ和Tau病理状况提高APP/PS1转基因小鼠的学习能力。
Acta Pharmacol Sin. 2017 Jan;38(1):9-28. doi: 10.1038/aps.2016.94. Epub 2016 Oct 3.
4
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance.小分子LX2343通过靶向淀粉样β蛋白的产生和清除来改善阿尔茨海默病模型小鼠的认知缺陷。
Acta Pharmacol Sin. 2016 Sep;37(10):1281-1297. doi: 10.1038/aps.2016.80. Epub 2016 Aug 29.
5
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.原花青素通过靶向β-淀粉样蛋白的产生和清除有效改善阿尔茨海默病模型小鼠的记忆障碍。
J Neurosci. 2013 Aug 7;33(32):13138-49. doi: 10.1523/JNEUROSCI.4790-12.2013.
6
"Positive biology": the centenarian lesson.“积极生物学”:百岁老人的经验。
Immun Ageing. 2012 Apr 23;9(1):5. doi: 10.1186/1742-4933-9-5.
7
Pathophysiology of age-related diseases.与年龄相关疾病的病理生理学。
Immun Ageing. 2009 Sep 8;6:12. doi: 10.1186/1742-4933-6-12.
8
Mechanisms of immunosenescence.免疫衰老的机制。
Immun Ageing. 2009 Jul 22;6:10. doi: 10.1186/1742-4933-6-10.