Ayres M A, Sulak P J
Department of Obstetrics and Gynecology, Scott & White Hospital/Texas A&M University, Temple 76508.
South Med J. 1991 Feb;84(2):266-9. doi: 10.1097/00007611-199102000-00029.
The manifestations of antiphospholipid antibodies in pregnancy are multiple and include maternal arterial and venous thrombosis, spontaneous abortion, intrauterine fetal death, intrauterine growth retardation, and preeclampsia. Maternal complications may also arise in the puerperium with the development of an autoimmune pleuropulmonary postpartum syndrome. Currently, there is confusion in the literature regarding appropriate treatment of patients known to possess these antibodies. We have reported the case of a patient at 29 weeks' gestation who had elevated blood pressure, proteinuria, and early intrauterine growth retardation. Studies were positive for the presence of both lupus anticoagulant and anticardiolipin antibodies. After delivery, chest pain and a pleural effusion developed as further manifestations of the patient's autoimmune disease.
抗磷脂抗体在妊娠中的表现多种多样，包括母体动脉和静脉血栓形成、自然流产、宫内胎儿死亡、宫内生长受限和先兆子痫。产褥期也可能出现母体并发症，表现为自身免疫性产后胸膜肺综合征。目前，关于已知存在这些抗体的患者的适当治疗，文献中存在混淆。我们报告了一例妊娠29周的患者，该患者有血压升高、蛋白尿和早期宫内生长受限。检查发现狼疮抗凝物和抗心磷脂抗体均呈阳性。分娩后，胸痛和胸腔积液出现，成为该患者自身免疫性疾病的进一步表现。
