Kochenour N K, Branch D W, Rote N S, Scott J R
Obstet Gynecol. 1987 Mar;69(3 Pt 2):460-8.
Three women with antiphospholipid antibodies and a postpartum syndrome of pleuropulmonary disease, fever, and cardiac manifestations are presented. Each patient had either lupus anticoagulant or anticardiolipin antibodies or both, but did not have antinuclear antibodies or fulfill the criteria for the diagnosis of systemic lupus erythematosus. No infection or embolus was detected that could explain the pulmonary findings. All three patients had electrocardiographic abnormalities, and one patient developed a cardiomyopathy with extensive immunoglobulin G (IgG), IgM, IgA, and C3 deposition in the myocardium. In addition to the reported association between antiphospholipid antibodies and fetal loss, fetal growth retardation, and preeclampsia, we suggest that patients with antiphospholipid antibodies are at risk for a previously unreported and serious autoimmune postpartum syndrome.
本文介绍了三名患有抗磷脂抗体且出现产后胸膜肺部疾病、发热和心脏表现综合征的女性。每位患者都有狼疮抗凝物或抗心磷脂抗体，或两者皆有，但没有抗核抗体，也不符合系统性红斑狼疮的诊断标准。未检测到可解释肺部表现的感染或栓子。所有三名患者都有心电图异常，一名患者发展为心肌病，心肌中有广泛的免疫球蛋白G（IgG）、IgM、IgA和C3沉积。除了已报道的抗磷脂抗体与胎儿丢失、胎儿生长受限和先兆子痫之间的关联外，我们认为抗磷脂抗体患者有患一种先前未报道的严重自身免疫性产后综合征的风险。
