Heifets L B, Lindholm-Levy P J, Flory M
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Am Rev Respir Dis. 1991 Feb;143(2):268-70. doi: 10.1164/ajrccm/143.2.268.
Minimal inhibitory and bactericidal concentrations (MIC and MBC) of isoniazid and ethionamide were determined in 7H12 broth in experiments with 68 Mycobacterium avium strains and 14 wild drug-susceptible M. tuberculosis strains. MICs of isoniazid for M. tuberculosis were from 0.025 to 0.05 microgram/ml, and for M. avium from 0.6 to greater than 10.0 micrograms/ml. MICs of ethionamide for M. tuberculosis were from 0.3 to 1.25 micrograms/ml, and 42.7% of M. avium strains were within the same range. Isoniazid and ethionamide were highly bactericidal against M. tuberculosis, but they had very low bactericidal activity against M. avium.
在含有68株鸟分枝杆菌菌株和14株野生药物敏感结核分枝杆菌菌株的实验中，在7H12肉汤中测定了异烟肼和乙硫异烟胺的最低抑菌浓度和最低杀菌浓度（MIC和MBC）。异烟肼对结核分枝杆菌的MIC为0.025至0.05微克/毫升，对鸟分枝杆菌的MIC为0.6至大于10.0微克/毫升。乙硫异烟胺对结核分枝杆菌的MIC为0.3至1.25微克/毫升，42.7%的鸟分枝杆菌菌株处于相同范围内。异烟肼和乙硫异烟胺对结核分枝杆菌具有高度杀菌活性，但对鸟分枝杆菌的杀菌活性非常低。
