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胃旁路手术的五年结果:Roux袢长度有影响。

Five-year outcome with gastric bypass: Roux limb length makes a difference.

作者信息

Gleysteen John J

机构信息

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

出版信息

Surg Obes Relat Dis. 2009 Mar-Apr;5(2):242-7; discussion 247-9. doi: 10.1016/j.soard.2008.08.005. Epub 2008 Aug 19.

Abstract

BACKGROUND

Surgical reports have indicated that longer Roux limbs (150 cm) have greater or no effect on long-term weight loss in super-obese patients (body mass index [BMI]>or=50 kg/m2) and little effect in less obese patients.

METHODS

The weight loss outcomes through 5 years were compared in 3 sequential groups of patients, who underwent gastric bypass by 1 surgeon, and in whom the Roux limb lengths were different. Comparisons were made between 2 cohorts: those with a BMI of <50 (morbid obesity [MO]) and those with a BMI>or=50 kg/m2 (super obesity [SO]). Three groups of patients stratified by Roux limb lengths were compared: group 1, 41-61-cm Roux limb; group 2, 130-160-cm Roux limb; and group 3, 115-250-cm Roux limb (one third of small bowel). All comparisons were made using 2-way analysis of variance, and the interaction terms were not significant.

RESULTS

A comparable number of patients were in each group, and the average preoperative weights were similar; however, more than twice as many patients in groups 2 and 3 were SO than MO. The BMI loss and weight loss were similar in each group. The greater BMI cohort (SO) lost more weight than did the MO cohort (P<.001). The BMI change and weight change in the shorter Roux limb group were less than those in groups 2 or 3 (longer Roux limbs; P<.01-.05). This difference was established with the BMI by 18 months. The BMI change and weight loss were not different between groups 2 and 3, presumably because their mean Roux limb lengths were not different. A limited amount of weight gain or recidivism occurred in patients with 5 years of follow-up, and it was not different among the 3 groups.

CONCLUSION

The results of this study have shown that longer Roux limbs improve weight loss outcomes both early and late in SO patients but not in MO patients. Clinically used long lengths of Roux limbs are close enough to one third of the total small bowel length such that the weight outcomes were not different, and total length should not need to be measured operatively. The eventual changes attributed to recidivism were not affected by the Roux limb length.

摘要

背景

手术报告表明,较长的 Roux 袢(150 cm)对超级肥胖患者(体重指数[BMI]≥50 kg/m²)的长期体重减轻影响更大或无影响,而对肥胖程度较轻的患者影响较小。

方法

比较了由 1 名外科医生实施胃旁路手术、Roux 袢长度不同的 3 组连续患者 5 年的体重减轻结果。对 2 个队列进行了比较:BMI<50(病态肥胖[MO])的患者和 BMI≥50 kg/m²(超级肥胖[SO])的患者。比较了按 Roux 袢长度分层的 3 组患者:第 1 组,Roux 袢长度为 41 - 61 cm;第 2 组,Roux 袢长度为 130 - 160 cm;第 3 组,Roux 袢长度为 115 - 250 cm(小肠的三分之一)。所有比较均采用双向方差分析,交互项无统计学意义。

结果

每组患者数量相当,术前平均体重相似;然而,第 2 组和第 3 组中超级肥胖患者的数量是病态肥胖患者的两倍多。每组的 BMI 降低和体重减轻情况相似。BMI 较高的队列(超级肥胖)比病态肥胖队列减重更多(P<0.001)。较短 Roux 袢组的 BMI 变化和体重变化小于第 2 组或第 3 组(Roux 袢较长;P<0.01 - 0.05)。这种差异在 18 个月时通过 BMI 得以确立。第 2 组和第 3 组之间的 BMI 变化和体重减轻无差异,可能是因为它们的平均 Roux 袢长度没有差异。在 5 年随访期内,患者出现了有限的体重增加或复发情况,3 组之间无差异。

结论

本研究结果表明,较长的 Roux 袢可改善超级肥胖患者早期和晚期的体重减轻效果,但对病态肥胖患者无效。临床上使用的 Roux 袢长度接近小肠总长度的三分之一,因此体重减轻结果无差异,手术时无需测量总长度。复发导致最终的变化不受 Roux 袢长度的影响。

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