Johansson Pia M, de Leon Antonio Ponce, Sadigh Siv, Tillgren Per E, Rehnberg Clas
Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
Eur J Public Health. 2009 Jan;19(1):100-5. doi: 10.1093/eurpub/ckn102. Epub 2008 Nov 7.
Multiple control areas and time-series analyses have been recommended for effect evaluations of community-based health promotion. Large fluctuations, maybe due to chance, among the areas and over the years might obscure the intervention effect.
A quasi-experimental time-series analysis with several control areas was performed as an effect evaluation of a community-based elderly safety promotion program. The program was implemented during 1995-99 in a community in the Stockholm Metropolitan area (population +65 years: 5500; number of first hip fractures in 1995: 60). Four control areas were selected based on similar hip fracture-related characteristics as the intervention community, complemented with two larger control areas. The time series covered 6 years pre-intervention (1990-95) and 6 years post-intervention (1996-2001). The study population was divided into two age groups and gender, resulting in 28 panels. The first hip fracture incidence was obtained from the Swedish national in-patient register.
The time series revealed no discernible pattern, and conventional analyses showed no conclusive results. A multivariate analysis, examining the time trends by employing the intra-annual and intra-panel variance, revealed the underlying trends in hip fracture rates. Comparisons between predicted numbers of hip fractures in the intervention and control areas was enabled, which resulted in 14 less hip fractures in the intervention community than expected from the control communities. If one extreme value was altered, the result changed considerably.
Effect evaluations of community-based health promotion programs using time-series from small communities might give faulty results, if statistical modelling is not employed.
对于基于社区的健康促进效果评估,推荐采用多个对照区域和时间序列分析。各区域之间以及多年来可能由于偶然因素出现的大幅波动,可能会掩盖干预效果。
进行了一项带有多个对照区域的准实验性时间序列分析,作为对一个基于社区的老年人安全促进项目的效果评估。该项目于1995 - 1999年在斯德哥尔摩大都市区的一个社区实施(65岁及以上人口:5500人;1995年首次髋部骨折病例数:60例)。根据与干预社区相似的髋部骨折相关特征选择了四个对照区域,并补充了两个较大的对照区域。时间序列涵盖干预前6年(1990 - 1995年)和干预后6年(1996 - 2001年)。研究人群按年龄组和性别分为28个小组。首次髋部骨折发病率来自瑞典国家住院登记处。
时间序列未显示出明显模式,传统分析也未得出确凿结果。通过采用年内和组内方差来检验时间趋势的多变量分析揭示了髋部骨折率的潜在趋势。能够对干预区域和对照区域的髋部骨折预测数量进行比较,结果显示干预社区的髋部骨折病例数比对照社区预期的少14例。如果改变一个极端值,结果会有很大变化。
如果不采用统计建模,利用小社区时间序列对基于社区的健康促进项目进行效果评估可能会得出错误结果。