质粒编码的调节因子激活赋予肠道致病性大肠杆菌菌株溶菌酶抗性的因子。
The plasmid-encoded regulator activates factors conferring lysozyme resistance on enteropathogenic Escherichia coli strains.
作者信息
Salinger Nina, Kokona Bashkim, Fairman Robert, Okeke Iruka N
机构信息
Department of Biology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041, USA.
出版信息
Appl Environ Microbiol. 2009 Jan;75(1):275-80. doi: 10.1128/AEM.01734-08. Epub 2008 Nov 7.
Abstract
We demonstrate that enhanced lysozyme resistance of enteropathogenic Escherichia coli requires the plasmid-encoded regulator, Per, and is mediated by factors outside the locus for enterocyte effacement. EspC, a Per-activated serine protease autotransporter protein, conferred enhanced resistance on nonpathogenic E. coli, and a second Per-regulated, espC-independent lysozyme resistance mechanism was identified.
摘要
我们证明，肠道致病性大肠杆菌对溶菌酶的抗性增强需要质粒编码的调节因子Per，并且由肠细胞脱落位点以外的因子介导。EspC是一种Per激活的丝氨酸蛋白酶自转运蛋白，赋予非致病性大肠杆菌增强的抗性，并且鉴定出了第二种Per调节的、不依赖EspC的溶菌酶抗性机制。
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