一种新型L-氨基酸连接酶由丁香假单胞菌菜豆致病变种1448A的菜豆毒素生物合成基因簇中的一个基因编码。
A novel L-amino acid ligase is encoded by a gene in the phaseolotoxin biosynthetic gene cluster from Pseudomonas syringae pv. phaseolicola 1448A.
作者信息
Arai Toshinobu, Kino Kuniki
机构信息
Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University, Tokyo, Japan.
出版信息
Biosci Biotechnol Biochem. 2008 Nov;72(11):3048-50. doi: 10.1271/bbb.80439. Epub 2008 Nov 7.
PMID:18997422
Abstract
In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPPH_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various hetero-dipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.
摘要
在丁香假单胞菌菜豆致病变种1448A的菜豆毒素生物合成基因簇中，PSPPH_4299基因编码一种新型L-氨基酸连接酶。PSPPH_4299蛋白以ATP依赖的方式合成了多种含碱性氨基酸的杂二肽，还合成了菜豆毒素支架的一部分——丙氨酰-高精氨酸。
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