Li Xiaoyong, Borhan Babak
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
J Am Chem Soc. 2008 Dec 3;130(48):16126-7. doi: 10.1021/ja805058t.
A microscale protocol for determination of absolute configurations of 2,3-epoxy alcohols is described. 2,3-Disubstituted (cis and trans), 2,2-disubstituted, 2,2,3-trisubstituted, and 2,3,3-trisubstituted epoxy alcohols rendered prominent ECCD signals upon complexing with a Lewis acidic porphyrin tweezer and consequently provide straightforward assignment of chirality for epoxy alcohols. This method proved to be rapid, simple, sensitive, and reliable for the class of molecules listed above.
本文描述了一种用于测定2,3-环氧醇绝对构型的微观方法。2,3-二取代（顺式和反式）、2,2-二取代、2,2,3-三取代和2,3,3-三取代的环氧醇与路易斯酸性卟啉镊子络合后产生显著的电子圆二色（ECCD）信号，因此可直接确定环氧醇的手性。对于上述分子类别，该方法被证明是快速、简单、灵敏且可靠的。
