利用薄层色谱法测定仲醇的绝对构型。
Determination of absolute configuration of secondary alcohols using thin-layer chromatography.
机构信息
Department of Chemistry, 1102 Natural Sciences II, University of California-Irvine, Irvine, California 92627, United States.
出版信息
J Org Chem. 2013 May 3;78(9):4594-8. doi: 10.1021/jo400432q. Epub 2013 Apr 17.
Abstract
A new implementation of the competing enantioselective conversion (CEC) method was developed to qualitatively determine the absolute configuration of enantioenriched secondary alcohols using thin-layer chromatography. The entire process for the method requires approximately 60 min and utilizes micromole quantities of the secondary alcohol being tested. A number of synthetically relevant secondary alcohols are presented. Additionally, (1)H NMR spectroscopy was conducted on all samples to provide evidence of reaction conversion that supports the qualitative method presented herein.
摘要
开发了一种新的竞争对映选择性转化（CEC）方法的实施，以使用薄层色谱法定性确定对映体富集的仲醇的绝对构型。该方法的整个过程大约需要 60 分钟，并且使用被测试的仲醇的毫摩尔量。呈现了一些合成相关的仲醇。此外，对所有样品进行了 (1)H NMR 光谱分析，以提供支持本文所提出的定性方法的反应转化率的证据。
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