Murray H W, Granger A M, Mohanty S K
Division of Infectious Diseases, Cornell University Medical College, New York, NY 10021.
J Infect Dis. 1991 Mar;163(3):622-4. doi: 10.1093/infdis/163.3.622.
The capacity of Leishmania donovani-infected BALB/c mice to respond to conventional chemotherapy with pentavalent antimony (Sb) is T cell dependent and, in nude mice, can be restored in part by treatment with the T cell lymphokines, interferon-gamma (IFN-gamma) or interleukin-2 (IL-2). To document the presumed role of endogenous IFN-gamma and IL-2 in responsiveness to antileishmanial chemotherapy in the T cell-intact host, L. donovani-infected euthymic BALB/c mice were treated with anti-IFN-gamma or anti-IL-2 monoclonal antibodies (MAbs) before and after Sb administration. Treatment with MAbs exacerbated visceral infection but did not inhibit the in vivo efficacy of Sb. Thus, while combination therapy of Sb plus IFN-gamma or IL-2 may prove beneficial in T cell-deficient hosts with visceral leishmaniasis, T cell activities other than or in addition to IFN-gamma or IL-2 production may mediate in vivo responsiveness to antileishmanial chemotherapy in the euthymic host.
感染杜氏利什曼原虫的BALB/c小鼠对五价锑（Sb）常规化疗的反应能力依赖于T细胞，在裸鼠中，用T细胞淋巴因子、干扰素-γ（IFN-γ）或白细胞介素-2（IL-2）治疗可部分恢复其反应能力。为了证明内源性IFN-γ和IL-2在T细胞完整宿主对抗利什曼原虫化疗反应中的假定作用，在给予Sb之前和之后，用抗IFN-γ或抗IL-2单克隆抗体（MAb）治疗感染杜氏利什曼原虫的正常胸腺BALB/c小鼠。用MAb治疗会加剧内脏感染，但不会抑制Sb的体内疗效。因此，虽然Sb加IFN-γ或IL-2的联合治疗可能对内脏利什曼病的T细胞缺陷宿主有益，但除了产生IFN-γ或IL-2之外或之外的T细胞活性可能介导正常胸腺宿主对抗利什曼原虫化疗的体内反应。
