Murray H W, Hariprashad J, Fichtl R E
Division of Infectious Diseases, Cornell University Medical College, New York, New York 10021.
Antimicrob Agents Chemother. 1993 Jul;37(7):1504-5. doi: 10.1128/AAC.37.7.1504.
In experimental visceral leishmaniasis, euthymic but not athymic (nude) BALB/c mice respond to conventional treatment with pentavalent antimony, indicating that the in vivo efficacy of antimony is T cell dependent. This finding correlates with frequent antimony treatment failures for T-cell-deficient patients with visceral leishmaniasis. To determine whether the in vivo efficacies of alternative antileishmanial agents also require T cells, Leishmania donovani-infected euthymic and nude BALB/c mice were treated with pentamidine or amphotericin B. Pentamidine induced leishmanistatic activity in euthymic mice but had little effect in nude mice. In contrast, amphotericin B exerted potent leishmanicidal activities in both euthymic and nude animals. These results suggest that amphotericin B may be of particular use for T-cell-deficient patients with visceral leishmaniasis.
在实验性内脏利什曼病中，正常胸腺的BALB/c小鼠而非无胸腺（裸）的BALB/c小鼠对五价锑的传统治疗有反应，这表明锑的体内疗效依赖于T细胞。这一发现与内脏利什曼病的T细胞缺陷患者频繁出现锑治疗失败的情况相关。为了确定其他抗利什曼原虫药物的体内疗效是否也需要T细胞，用喷他脒或两性霉素B对感染杜氏利什曼原虫的正常胸腺和裸BALB/c小鼠进行治疗。喷他脒在正常胸腺小鼠中诱导了利什曼原虫抑制活性，但对裸鼠几乎没有影响。相反，两性霉素B在正常胸腺和裸鼠中均发挥了强大的杀利什曼原虫活性。这些结果表明，两性霉素B可能对内脏利什曼病的T细胞缺陷患者特别有用。
