Kaczor D A, Bickford N N, Triplett D A
Department of Coagulation, Lehigh Valley Hospital Center, Allentown, Pennsylvania 18105.
Am J Clin Pathol. 1991 Mar;95(3):408-11. doi: 10.1093/ajcp/95.3.408.
Until recently, the laboratory identification of lupus anticoagulants (LA) was not considered important. Often LA were regarded as a nuisance, resulting in factor assays and other coagulation tests with inconclusive results. However, the recognition of important clinical complications associated with the presence of LA has resulted in an emphasis on the detection of this phospholipid-dependent inhibitor. Most studies have evaluated the sensitivity of various screening or confirmatory procedures used in establishing the diagnosis of LA. The authors have focused on the variables involved in the mixing studies used to identify the presence of a circulating inhibitor. To detect the latter, attention to the ratio of patient plasma to normal plasma is important, particularly in the case of a minimally prolonged APTT. Also the source of "normal" plasma must be platelet poor to maximize sensitivity in the case of a weak LA.
直到最近，狼疮抗凝物（LA）的实验室鉴定才被认为是重要的。LA常常被视为一种麻烦，导致因子测定和其他凝血试验结果不确定。然而，认识到与LA存在相关的重要临床并发症后，人们开始重视这种磷脂依赖性抑制剂的检测。大多数研究评估了用于LA诊断的各种筛查或确证程序的敏感性。作者们关注了用于识别循环抑制剂存在的混合试验中涉及的变量。为了检测后者，关注患者血浆与正常血浆的比例很重要，尤其是在活化部分凝血活酶时间（APTT）轻度延长的情况下。同样，“正常”血浆的来源必须是血小板含量低的，以便在LA较弱的情况下最大限度地提高敏感性。
