Gandy S J, Lambert M, Belch J J F, Cavin I D, Crowe E, Littleford R, Macfarlane J A, Matthew S Z, Martin P, Nicholas R S, Struthers A D, Sullivan F, Waugh S A, White R D, Weir-McCall J R, Houston J G
NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee DD1 9SY, UK; NHS Tayside Medical Physics, Ninewells Hospital, Dundee DD1 9SY, UK.
Medical Research Institute, College of Medicine, University of Dundee, Dundee DD1 9SY, UK.
Clin Radiol. 2015 Jun;70(6):595-603. doi: 10.1016/j.crad.2015.02.003. Epub 2015 Mar 16.
To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.
Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.
For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.
Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.
评估在单次检查中同时进行心脏磁共振成像（CMR）和对比增强（CE）全身磁共振血管造影（WB-MRA）技术的联合方案。
招募了心血管疾病（CVD）低-中度风险的无症状志愿者（n = 48）。该方案分为四个部分：（1）左心室（LV）结构和功能的CMR；（2）头部、颈部和胸部的CE-MRA，随后是下肢远端；（3）CMR左心室“钆延迟增强”评估；（4）腹部和骨盆的CE-MRA，随后是下肢近端。多名观察者进行图像分析。
对于CMR，平均射血分数（EF）为67.3±4.8%，平均左心室质量（LVM）为100.3±22.8 g。观察者内EF的重复性范围为2.1 - 4.7%，LVM为9 - 12 g。观察者间EF的重复性为8.1%，LVM为19.1 g。未观察到左心室延迟心肌强化。对于WB-MRA，在3.6%的血管节段可见一定程度的管腔狭窄或狭窄（涉及48名志愿者中的29名），在评估的1488个血管节段中，观察者间的放射学意见一致性为96.7%。
在临床MRI系统上可在单次检查中对WB-MRA和CMR进行联合评估。相关分析技术具有可重复性，可能适用于更大规模的心血管MRI研究。
