Peeters Anna, Magliano Dianna J, Stevens June, Duncan Bruce B, Klein Ronald, Wong Tien Y
Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia.
Arch Ophthalmol. 2008 Nov;126(11):1554-60. doi: 10.1001/archopht.126.11.1554.
To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD).
A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years in 1987 to 1989, were followed up over 6 years. The percentage change in WHR during follow-up was ranked into sex-specific deciles; an increase in WHR was defined as the top 10% of change and a decrease in WHR as the bottom 10%. The association of increased or decreased WHR and presence of AMD at follow-up was determined using logistic regression adjusting for potential confounders.
The average change in WHR was an increase of 2%, ranging from a decrease of 44% to an increase of 102%. A decrease in WHR of 3% or more was associated with 29% lower odds of any AMD (odds ratio = 0.71; 95% confidence interval, 0.52-0.97). This effect was most pronounced among obese participants at baseline, where a decrease in WHR was associated with 59% lower odds of AMD (odds ratio = 0.41; 95% confidence interval, 0.20-0.82).
Middle-aged persons who had a 3% or greater reduction in WHR over time were less likely to have AMD, particularly among those who were initially obese.
研究腹部肥胖指标腰臀比（WHR）的变化与年龄相关性黄斑变性（AMD）之间的关联。
对1987年至1989年年龄在45至64岁之间的12515名基于人群队列研究的参与者进行了6年的随访。随访期间WHR的百分比变化按性别分为十分位数；WHR增加定义为变化的前10%，WHR减少定义为变化的后10%。使用逻辑回归分析调整潜在混杂因素，确定随访时WHR增加或减少与AMD存在之间的关联。
WHR的平均变化为增加2%，范围从减少44%到增加102%。WHR减少3%或更多与任何AMD的患病几率降低29%相关（优势比 = 0.71；95%置信区间，0.52 - 0.97）。这种效应在基线时肥胖的参与者中最为明显，其中WHR降低与AMD的患病几率降低59%相关（优势比 = 0.41；95%置信区间，0.20 - 0.82）。
随着时间推移WHR降低达3%或更多的中年人患AMD的可能性较小，尤其是那些最初肥胖的人。
