Moeini H A, Masoudpour H, Ghanbari H
Feiz Hospital, Opthamology Department, Isfahan, University of Medical Sciences, Islamic Republic of Iran.
Br J Ophthalmol. 2005 Aug;89(8):964-6. doi: 10.1136/bjo.2005.066241.
Age related macular degeneration (ARMD) is the most frequent cause of blindness among the elderly. Obesity may be one of the risk factors of ARMD as suggested, yet not proved, by several studies. This study assesses the relation between body mass index (BMI) and the incidence of ARMD METHODS: This case-control study included 50 patients with ARMD and 80 subjects who were adjusted for age, sex, cigarette smoking, blood pressure, and diabetes. Data analysis was performed by SPSS V9.0 using Student's t and chi2 tests.
42% of the subjects in the case group and 35% of those in the control group were men. Mean age of subjects in the case and control groups was 69.9 years (62-77 years) and 64.08 years (56-71 years), respectively. Mean BMI measured 25.38 (range 21-29) and 30.24 (26-34) in the case and control groups, respectively (p>0.05). 12% of subjects in the case group were obese, 42% were overweight, and 14% were lean. 22.5% of subjects in the control group were obese, 45% were overweight, and 7.5% were lean (p>0.05).
43% of patients in this study were aged 70 years or older, which is similar to other studies. There was no significant difference in BMI between the case and control groups. Recent studies indicate that obesity is a probable risk factor for progression of ARMD, but there is no significant relation with the presence of ARMD. With multifactorial analysis, the authors could identify no significant relation between the presence of ARMD and the studied risk factors.
年龄相关性黄斑变性（ARMD）是老年人失明的最常见原因。一些研究表明肥胖可能是ARMD的危险因素之一，但尚未得到证实。本研究评估体重指数（BMI）与ARMD发病率之间的关系。方法：本病例对照研究纳入了50例ARMD患者和80名按年龄、性别、吸烟、血压和糖尿病进行匹配的受试者。使用SPSS V9.0软件进行数据分析，采用Student's t检验和卡方检验。
病例组42%的受试者为男性，对照组为35%。病例组和对照组受试者的平均年龄分别为69.9岁（62 - 77岁）和64.08岁（56 - 71岁）。病例组和对照组的平均BMI分别为25.38（范围21 - 29）和30.24（26 - 34）（p>0.05）。病例组12%的受试者肥胖，42%超重，14%偏瘦。对照组22.5%的受试者肥胖，45%超重，7.5%偏瘦（p>0.05）。
本研究中43%的患者年龄在70岁及以上，这与其他研究相似。病例组和对照组之间的BMI无显著差异。近期研究表明肥胖可能是ARMD进展的危险因素，但与ARMD的发生无显著关系。通过多因素分析，作者未发现ARMD的存在与所研究的危险因素之间存在显著关系。
