Wakeley John, Sargsyan Ori
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Genetics. 2009 Jan;181(1):341-5. doi: 10.1534/genetics.108.092460. Epub 2008 Nov 10.
We suggest two extensions of the coalescent effective population size of Sjödin et al. (2005) and make a third, practical point. First, to bolster its relevance to data and allow comparisons between models, the coalescent effective size should be recast as a kind of mutation effective size. Second, the requirement that the coalescent effective population size must depend linearly on the actual population size should be lifted. Third, even if the coalescent effective population size does not exist in the mathematical sense, it may be difficult to reject Kingman's coalescent using genetic data.
我们提出了对舍丁等人(2005年)合并有效种群大小的两种扩展,并提出了第三个实际要点。首先,为增强其与数据的相关性并允许模型间的比较,合并有效大小应被重新定义为一种突变有效大小。其次,应摒弃合并有效种群大小必须与实际种群大小呈线性依赖的要求。第三,即使合并有效种群大小在数学意义上不存在,使用遗传数据也可能难以否定金曼合并理论。