Krogsgaard O W
Eur J Nucl Med. 1976;1(1):15-7.
The radiochemical purity of preparations for 99mTc-bone-scanning was tested using thin-layer chromatography and electrophoresis. The investigation included ten commercial kits, comprising four types of phosphorus compounds, i.e. sodium polyphosphate, sodium pyrophosphate, disodium diphosphonate, and sodium monofluorophosphate. Out-spoken differences in the content of free pertechnetate were found between the different kits. The contents in preparations from the same kit were fairly constant, but in some cases a change could be referred to the age of the 99mTc-generator or the time of analysis. No significant difference was found between preparations made from eluate with and without oxidizer. A 99mTc-tin-colloid was sporadically present in the preparations.
采用薄层色谱法和电泳法检测了99mTc骨扫描制剂的放射化学纯度。该研究包括十种商用试剂盒，包含四种磷化合物，即多聚磷酸钠、焦磷酸钠、二膦酸盐二钠和单氟磷酸钠。不同试剂盒之间游离高锝酸盐的含量存在明显差异。同一试剂盒制剂中的含量相当稳定，但在某些情况下，变化可能与99mTc发生器的使用时长或分析时间有关。在使用和未使用氧化剂的洗脱液制备的制剂之间未发现显著差异。制剂中偶尔会出现99mTc锡胶体。
