使用预测性生物标志物来选择晚期结直肠癌患者接受表皮生长因子受体抗体治疗。 - Suppr

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Using predictive biomarkers to select patients with advanced colorectal cancer for treatment with epidermal growth factor receptor antibodies.

作者信息

Wong Rachel, Cunningham David

出版信息

J Clin Oncol. 2008 Dec 10;26(35):5668-70. doi: 10.1200/JCO.2008.19.5024. Epub 2008 Nov 10.

DOI:10.1200/JCO.2008.19.5024

PMID:19001346

Abstract

摘要

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Using predictive biomarkers to select patients with advanced colorectal cancer for treatment with epidermal growth factor receptor antibodies.使用预测性生物标志物来选择晚期结直肠癌患者接受表皮生长因子受体抗体治疗。

J Clin Oncol. 2008 Dec 10;26(35):5668-70. doi: 10.1200/JCO.2008.19.5024. Epub 2008 Nov 10.

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.野生型BRAF是转移性结直肠癌对帕尼单抗或西妥昔单抗产生反应所必需的。

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Relationship between colorectal cancer biomarkers and response to epidermal growth factor receptor monoclonal antibodies.结直肠癌生物标志物与表皮生长因子受体单克隆抗体反应之间的关系

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The forest and the trees: pathways and proteins as colorectal cancer biomarkers.森林与树木：作为结直肠癌生物标志物的通路与蛋白质

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Are we ready to restrict EGFR therapy to quadruple-negative colorectal cancer?我们准备好将表皮生长因子受体（EGFR）治疗限制于四阴性结直肠癌了吗？

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Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.分析PTEN、BRAF和EGFR状态以确定野生型KRAS转移性结肠癌患者从西妥昔单抗治疗中获益的情况。

J Clin Oncol. 2009 Dec 10;27(35):5924-30. doi: 10.1200/JCO.2008.21.6796. Epub 2009 Nov 2.

Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?结直肠癌的预后与预测性分子生物标志物：抗 EGFR 治疗是否需要 KRAS 和 BRAF 野生型状态？

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EGFR FISH in colorectal cancer: what is the current reality?结直肠癌中的表皮生长因子受体荧光原位杂交技术：当前现状如何？

Lancet Oncol. 2008 May;9(5):402-3. doi: 10.1016/S1470-2045(08)70109-8.

KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature.结直肠癌肿瘤中的KRAS突变特征与西妥昔单抗反应特征显著重叠。

J Clin Oncol. 2008 May 1;26(13):2228-30; author reply 2230-1. doi: 10.1200/JCO.2007.15.9186.

EGFR antibodies in colorectal cancer: where do they belong?结直肠癌中的表皮生长因子受体抗体：它们的归属在哪里？

J Clin Oncol. 2010 Nov 1;28(31):4668-70. doi: 10.1200/JCO.2010.29.3407. Epub 2010 Oct 4.

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Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer.外泌体微小RNA：小分子，对结直肠癌有重大影响

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L-Lactate dehydrogenase B may be a predictive marker for sensitivity to anti-EGFR monoclonal antibodies in colorectal cancer cell lines.L-乳酸脱氢酶B可能是结直肠癌细胞系中抗表皮生长因子受体单克隆抗体敏感性的预测标志物。

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Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dream.结直肠癌的分子特征与生物标志物鉴定：迈向精准医学梦想的实现

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Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.不同的长 RNA 被差异化分拣到结直肠癌细胞分泌的细胞外囊泡中。

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