Similä S, Kauppila A, Ylikorkala O, Koivisto M, Mäkelä P, Haapalahti J
Eur J Pediatr. 1977 Feb 21;124(3):173-7. doi: 10.1007/BF00452108.
The plasma concentration of ACTH (by radioimmunoassay) was measured in 56 healthy parturients and their newborns. Umbilical cord and maternal venous blood were collected immediately after delivery. In addition one venous blood sample was taken from 50 newborns at the age of 15, 30, 60 min, 2, 6, 12, or 24 h. The maternal and cord plasma ACTH levels were higher than the levels in healthy nonpregnant women. There are no differences between the mean maternal (226 +/- 146 pg/ml) and cord (226 +/- 147 pg/ml) values of ACTH. The high ACTH levels of cord plasma remain unchanged for 30 min, decrease significantly during the 1-6 h after birth, because of the elimination process of the circulated foetal ACTH, and increase over the next 12-24 h and slightly thereafter indicating an initiation of neonatal pituitary ACTH secretion. The plasma ACTH level in the mothers with membranes ruptured for 1-5 h was significantly (P less than 0.05) higher compared with that in the mothers with membranes ruptured for less than 1 h. However, the duration of ruptured membranes appeared to have no effect on the cord blood ACTH level.
通过放射免疫分析法测定了56名健康产妇及其新生儿的促肾上腺皮质激素（ACTH）血浆浓度。分娩后立即采集脐带血和母体静脉血。此外，还从50名新生儿出生后15、30、60分钟、2、6、12或24小时采集了一份静脉血样本。产妇和脐带血浆ACTH水平高于健康未孕女性。产妇（226±146 pg/ml）和脐带（226±147 pg/ml）ACTH的平均水平无差异。脐带血浆中较高的ACTH水平在30分钟内保持不变，出生后1 - 6小时因循环中的胎儿ACTH的清除过程而显著下降，在接下来的12 - 24小时及之后略有上升，表明新生儿垂体ACTH分泌开始。胎膜破裂1 - 5小时的母亲血浆ACTH水平与胎膜破裂少于1小时的母亲相比显著升高（P＜0.05）。然而，胎膜破裂持续时间似乎对脐带血ACTH水平没有影响。
