Gemelli M, Mamì C, Manganaro R, De Luca F, Saja A, Costa G
Istituto di Clinica Pediatrica, Università di Messina, Italy.
J Endocrinol Invest. 1988 Jun;11(6):395-8. doi: 10.1007/BF03349064.
Plasma adrenocorticotropic hormone (ACTH) and beta-endorphin (beta-EP) concentrations were measured by radioimmunoassay in 122 newborns, born vaginally after spontaneous labor between the 38th and the 41st week of pregnancy. Blood samples were taken from umbilical cord in 10 newborns and from antecubital vein in the remaining 112 newborns, divided into 8 groups aged from 12 h to 7 days. The mean (+/- SE) ACTH concentrations in cord plasma were 81.87 +/- 10.16 pg/ml and decreased significantly (p less than 0.01) at the 24th h of life (49.09 +/- 6.93 pg/ml). Afterwards mean ACTH plasma concentrations fluctuated around the latter values. The mean (+/- SE) B-EP concentrations in cord plasma were 21.96 +/- 3.12 pmol/l and decreased significantly at the 24th h of life (13.43 +/- 2.08 pmol/l; p less than 0.01). From the 24th h to the 7th day the mean plasma concentrations of beta-EP were not significantly different. ACTH and beta-EP plasma levels were positively correlated (p less than 0.001) at delivery and during the first seven days of life.
采用放射免疫分析法测定了122例妊娠38至41周自然分娩的新生儿的血浆促肾上腺皮质激素（ACTH）和β-内啡肽（β-EP）浓度。10例新生儿取脐带血样，其余112例新生儿取肘前静脉血样，分为8组，年龄从12小时至7天。脐血浆中ACTH的平均（±标准误）浓度为81.87±10.16 pg/ml，出生后24小时显著降低（p<0.01）（49.09±6.93 pg/ml）。此后，ACTH血浆平均浓度围绕后一数值波动。脐血浆中β-EP的平均（±标准误）浓度为21.96±3.12 pmol/l，出生后24小时显著降低（13.43±2.08 pmol/l；p<0.01）。从出生后24小时至第7天，β-EP的血浆平均浓度无显著差异。分娩时及出生后前7天，ACTH和β-EP血浆水平呈正相关（p<0.001）。
