Kauppila A, Similä S, Ylikorkala O, Koivisto M, Mäkelä P, Haapalahti J
Br J Obstet Gynaecol. 1977 Feb;84(2):124-8. doi: 10.1111/j.1471-0528.1977.tb12538.x.
The effect of prenatal dexamethasone therapy (12, 8 and 4 mg doses given intramuscularly on three consecutive days) on ACTH levels in maternal plasma (n=33), mixed umbilical cord plasma (n=31) and plasma from the newborn (n=29) was studied, and the results were compared with those obtained in 56 healthy parturients and 50 of their newborn. Maternal ACTH after delivery was significantly lower in the mothers treated with dexamethasone than in the control group. Cord ACTH values were similar in the two groups. ACTH levels fell during the early neonatal period, but only at 12 to 24 hours were the ACTH levels significantly lower in the dexamethasone group than in the controls. Gestational age, birth weight and the interval between the dexamethasone therapy and delivery had no significant effect on cord ACTH levels. Short-term prenatal dexamethasone therapy seemed to have very little effect on ACTH secretion in the mother, in the fetus and in the newborn.
研究了产前地塞米松治疗（连续三天肌肉注射12毫克、8毫克和4毫克剂量）对母体血浆（n = 33）、混合脐血血浆（n = 31）和新生儿血浆（n = 29）中促肾上腺皮质激素（ACTH）水平的影响，并将结果与56名健康产妇及其50名新生儿的结果进行了比较。接受地塞米松治疗的母亲产后母体ACTH显著低于对照组。两组的脐血ACTH值相似。新生儿早期ACTH水平下降，但仅在12至24小时，地塞米松组的ACTH水平显著低于对照组。胎龄、出生体重以及地塞米松治疗与分娩之间的间隔对脐血ACTH水平无显著影响。短期产前地塞米松治疗似乎对母亲、胎儿和新生儿的ACTH分泌影响很小。
