磷酸肌醇磷酸酶与疾病
Phosphoinositide phosphatases and disease.
作者信息
Majerus Philip W, York John D
机构信息
Division of Hematology, Washington University School of Medicine, Box 8125, St. Louis, MO 63110, USA.
出版信息
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S249-54. doi: 10.1194/jlr.R800072-JLR200. Epub 2008 Nov 11.
Abstract
The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase isoforms. We also discuss recent discoveries that link mutations in phosphoinositide phosphatases to disease.
摘要
近年来，肌醇信号传导领域有了极大的扩展。鉴于已有许多关于磷酸肌醇激酶的综述，我们选择将讨论限制在肌醇脂水解方面，重点关注磷酸酶，并简要提及脂肪酶同工型。我们还将讨论最近将磷酸肌醇磷酸酶突变与疾病联系起来的发现。
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