Stroke Unit, Hvidovre University Hospital, Hvidovre, Denmark.
Neuroepidemiology. 2009;32(1):47-52. doi: 10.1159/000170906. Epub 2008 Nov 12.
Age-related hormonal factors are thought to be related to the gender gap in longevity. Testing the hypothesis that survival is best in young premenopausal women we studied the effect of age on 1-week mortality in stroke patients.
A registry was started in 2001 with the aim of registering all hospitalized patients in Denmark. The patients' risk factors, stroke severity and CT scan were evaluated. A total of 25,607 patients (63%) gave complete information on all risk factors and were used in the analysis. Independent predictors of survival were identified by means of multiple logistic regression.
The probability of death within 1 week adjusted for stroke severity, stroke type and risk factors was highly age-dependent in both men and women. Up to the age of 50 years, the 1-week female/male mortality rates paralleled being slightly (15%) but insignificantly better in women. While mortality increased almost linearly in women over the entire age range, it increased steeply in men from the age of 50 and at the age of 80 years survival was 80% better in women.
The female stroke survival advantage applies to all ages. It increases with age due to a steeply increase of mortality in middle-aged and elderly men.
与年龄相关的激素因素被认为与长寿方面的性别差异有关。为了验证这样一种假设，即生存能力在年轻的绝经前女性中最佳，我们研究了年龄对中风患者一周内死亡率的影响。
我们于 2001 年启动了一项注册研究，旨在登记丹麦所有住院患者。评估了患者的危险因素、中风严重程度和 CT 扫描。共有 25607 名（63%）患者提供了所有危险因素的完整信息，并用于分析。通过多元逻辑回归确定了生存的独立预测因素。
在调整了中风严重程度、中风类型和危险因素后，1 周内死亡的概率在男性和女性中均高度依赖年龄。在 50 岁之前，女性的 1 周死亡率/男性死亡率略低（15%），但差异无统计学意义。虽然女性的死亡率在整个年龄段几乎呈线性增加，但男性从 50 岁开始急剧增加，80 岁时女性的生存率提高了 80%。
女性中风后生存优势适用于所有年龄段。由于中老年男性死亡率急剧增加，这一优势随着年龄的增长而增加。
