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人类衰老的生物人口学。

Biodemography of human ageing.

机构信息

Max Planck Institute for Demographic Research, Konrad-Zuse-Strasse 1, D-18057 Rostock, Germany.

出版信息

Nature. 2010 Mar 25;464(7288):536-42. doi: 10.1038/nature08984.

DOI:10.1038/nature08984
PMID:20336136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4010874/
Abstract

Human senescence has been delayed by a decade. This finding, documented in 1994 and bolstered since, is a fundamental discovery about the biology of human ageing, and one with profound implications for individuals, society and the economy. Remarkably, the rate of deterioration with age seems to be constant across individuals and over time: it seems that death is being delayed because people are reaching old age in better health. Research by demographers, epidemiologists and other biomedical researchers suggests that further progress is likely to be made in advancing the frontier of survival - and healthy survival - to even greater ages.

摘要

人类衰老已被推迟了十年。这一发现可追溯到 1994 年,此后得到了进一步证实,它是人类衰老生物学的一项重大发现,对个人、社会和经济都具有深远的影响。值得注意的是,个体之间以及随着时间的推移,衰老的速度似乎是恒定的:似乎死亡正在被推迟,因为人们在更健康的状态下达到了老年。人口统计学家、流行病学家和其他生物医学研究人员的研究表明,进一步推进生存——以及健康生存——的前沿可能会取得更大的进展,达到更高的年龄。

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2
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Eur J Ageing. 2008 Oct 28;5(4):279. doi: 10.1007/s10433-008-0100-x. eCollection 2008 Dec.
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Trends in senescent life expectancy.衰老期望寿命趋势。
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Healthcare (Basel). 2025 Jun 5;13(11):1352. doi: 10.3390/healthcare13111352.
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The 15-Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging.15年生存优势:免疫弹性作为健康衰老中的一种健康促进力量。
Aging Cell. 2025 Apr 23:e70063. doi: 10.1111/acel.70063.
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Compression of morbidity by interventions that steepen the survival curve.通过使生存曲线变陡的干预措施来压缩发病率。
Nat Commun. 2025 Apr 8;16(1):3340. doi: 10.1038/s41467-025-57807-5.
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Stochasticity Explains Nongenetic Inheritance of Lifespan and Apparent Trade-Offs between Reproduction and Aging.随机性解释了寿命的非遗传继承以及繁殖与衰老之间明显的权衡。
Aging Biol. 2023 Aug 4;1(1):20230012. doi: 10.59368/agingbio.20230012.
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