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Elevated first trimester soluble fibrin polymer is associated with adverse pregnancy outcome in thrombophilic patients.

作者信息

Paidas Michael J, Ku De-Hui W, Urban Gabriele, Hossain Nazli, Rebarber Andrei, Lockwood Charles J, Arkel Yale S

出版信息

Blood Coagul Fibrinolysis. 2008 Dec;19(8):824-6. doi: 10.1097/MBC.0b013e32830ebb5c.

DOI:10.1097/MBC.0b013e32830ebb5c
PMID:19002052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3036561/
Abstract
摘要

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Elevated first trimester soluble fibrin polymer is associated with adverse pregnancy outcome in thrombophilic patients.孕早期可溶性纤维蛋白聚合物升高与血栓形成倾向患者的不良妊娠结局相关。
Blood Coagul Fibrinolysis. 2008 Dec;19(8):824-6. doi: 10.1097/MBC.0b013e32830ebb5c.
2
Elevated first trimester maternal levels of soluble fibrin polymer are associated with lower birthweight in twin gestation.
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Impact of inherited thrombophilias on first and second trimester maternal serum markers for aneuploidy.遗传性血栓形成倾向对孕早期和孕中期非整倍体母体血清标志物的影响。
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Pregnant patients with thrombophilia and subsequent adverse pregnancy outcomes have a decreased first trimester response to thrombomodulin in an activated partial thromboplastin time (APTT) system.患有血栓形成倾向并随后出现不良妊娠结局的孕妇，在活化部分凝血活酶时间（APTT）系统中，孕早期对血栓调节蛋白的反应降低。
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Second-trimester maternal serum alpha-fetoprotein (MSAFP) is elevated in women with adverse pregnancy outcome associated with inherited thrombophilias.孕中期母体血清甲胎蛋白（MSAFP）在患有与遗传性血栓形成倾向相关不良妊娠结局的女性中升高。
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[Hereditary antithrombin deficiency--rare, but serious. Great risk of venous thromboembolism].
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Establishing Expectancy Values for Fibrin Monomer in Uncomplicated Pregnancy.建立正常妊娠中纤维蛋白单体的预期值。
TH Open. 2024 Jul 11;8(3):e283-e296. doi: 10.1055/s-0044-1788281. eCollection 2024 Jul.

本文引用的文献

1
Adverse pregnancy outcome, the uteroplacental interface, and preventive strategies.不良妊娠结局、子宫胎盘界面及预防策略。
Semin Perinatol. 2007 Aug;31(4):208-12. doi: 10.1053/j.semperi.2007.05.002.
2
Elevated first trimester maternal levels of soluble fibrin polymer are associated with lower birthweight in twin gestation.
Blood Coagul Fibrinolysis. 2006 Jul;17(5):343-6. doi: 10.1097/01.mbc.0000233363.65239.f8.
3
Pregnant patients with thrombophilia and subsequent adverse pregnancy outcomes have a decreased first trimester response to thrombomodulin in an activated partial thromboplastin time (APTT) system.患有血栓形成倾向并随后出现不良妊娠结局的孕妇，在活化部分凝血活酶时间（APTT）系统中，孕早期对血栓调节蛋白的反应降低。
J Thromb Haemost. 2004 May;2(5):840-1. doi: 10.1111/j.1538-7836.2004.00680.x.
4
The use of coagulation activation markers (soluble fibrin polymer, TpP, prothrombin fragment 1.2, thrombin-antithrombin, and D-dimer) in the assessment of hypercoagulability in patients with inherited and acquired prothrombotic disorders.凝血激活标志物（可溶性纤维蛋白聚合物、凝血酶原片段1.2、凝血酶 - 抗凝血酶复合物和D - 二聚体）在遗传性和获得性血栓前状态患者高凝状态评估中的应用。
Blood Coagul Fibrinolysis. 2002 Apr;13(3):199-205. doi: 10.1097/00001721-200204000-00005.
5
Coagulation activation markers do not correlate with the clinical risk of thrombosis in pregnant women.凝血激活标志物与孕妇血栓形成的临床风险无关。
Am J Obstet Gynecol. 2001 Feb;184(3):382-9. doi: 10.1067/mob.2001.109397.
6
Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium.有妊娠和产褥期血栓形成病史女性的凝血酶原和因子V突变
N Engl J Med. 2000 Feb 10;342(6):374-80. doi: 10.1056/NEJM200002103420602.
7
Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden.对有和没有凝血因子V莱顿突变的健康孕妇止血系统激活和凝血酶潜力的前瞻性评估。
Thromb Haemost. 1999 Oct;82(4):1232-6.
8
Prothrombin activation fragment (F1.2) is increased in pregnant patients with antiphospholipid antibodies.抗磷脂抗体阳性的孕妇血浆凝血酶原激活片段（F1.2）水平升高。
Thromb Res. 1997 Feb 1;85(3):177-83. doi: 10.1016/s0049-3848(97)00002-9.
9
Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium.正常妊娠和产褥期凝血酶生成及纤溶活性增强。
Obstet Gynecol. 1992 Jul;80(1):132-7.
10
Antiphospholipid antibody syndrome.
JAMA. 1992 Sep 16;268(11):1451-3.