1-(substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice.

作者信息

Chabala J C, Waits V B, Ikeler T, Patchett A A, Payne L, Peterson L H, Reamer R A, Hoogsteen K, Wyvratt M, Hanson W L

机构信息

Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.

出版信息

Experientia. 1991 Jan 15;47(1):51-3. doi: 10.1007/BF02041250.

1-(Substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi infections in mice. The most active compounds are the 1-(4-chlorobenzyl)- and 1-(3,4-dichlorobenzyl)-analogs (L-153,094 [2] and L-153,153 [4], resp.) which are approximately 7-fold more potent upon oral administration than nifurtimox (Lampit) in suppressing parasite levels in the blood of mice with acute Trypanosoma cruzi infections.