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盐生柽柳提取物对草酸钙结晶的抑制作用

Inhibition of crystallization of calcium oxalate by the extraction of Tamarix gallica L.

作者信息

Bensatal Ahmed, Ouahrani M R

机构信息

Laboratoire de Chimie, Université Zian Achour de Djelfa, Djelfa, Algeria.

出版信息

Urol Res. 2008 Dec;36(6):283-7. doi: 10.1007/s00240-008-0157-1. Epub 2008 Nov 11.

Abstract

The main objective is to study the inhibitor effect of acid fraction of the extract of Tamarix gallica L on the crystallization of calcium oxalate. The extract of Tamarix gallica L is very rich by acid compounds that are used as an inhibitor of nephrolithiasis (calcium oxalate). Our study of the calcium oxalate crystallization is based on the model of turbidimetry by means of a spectrophotometer. The calcium oxalate formation is induced by the addition of oxalate solutions of sodium and of calcium chloride. The addition of inhibitor with various concentrations enabled us to give information on the percentage of inhibition. The comparison between the turbidimetric slopes with and without inhibitor gives the effectiveness of inhibitor for the acid fraction. By comparing the photographs of with and without inhibitor, we concluded that the extract of Tamarix gallica L acts at the stage of growth. The acid fraction of the extract of Tamarix gallica L gives an activity remarkable in the formation of urinary lithiasis (calcium oxalate); this effectiveness is due to the presence of functions of acid.

摘要

主要目的是研究没食子柽柳提取物的酸性组分对草酸钙结晶的抑制作用。没食子柽柳提取物富含用作肾结石(草酸钙)抑制剂的酸性化合物。我们对草酸钙结晶的研究基于使用分光光度计的比浊法模型。通过添加草酸钠溶液和氯化钙来诱导草酸钙的形成。添加不同浓度的抑制剂使我们能够获得有关抑制百分比的信息。有抑制剂和无抑制剂时比浊斜率的比较给出了酸性组分抑制剂的有效性。通过比较有抑制剂和无抑制剂时的照片,我们得出结论,没食子柽柳提取物在生长阶段起作用。没食子柽柳提取物的酸性组分在尿路结石(草酸钙)形成中具有显著活性;这种有效性归因于酸性官能团的存在。

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