Lin H C, Liu G F, Wang A G, Kong L J, Wang X F, Fu J L
College of Animal Science and Technology & Key Laboratory for Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, Beijing, China.
Mol Biol Rep. 2009 Sep;36(7):1833-8. doi: 10.1007/s11033-008-9387-0. Epub 2008 Nov 11.
DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter size in Large White pigs. A total of 2,167 litter records from 420 sows genotyped at two SNP loci (LIF1 and LIF2) within LIF gene were analyzed to determine whether LIF influenced total number born (TNB) and number born alive (NBA). The results indicated that B allele at LIF1 locus and A allele at LIF2 locus seem to have advantageous effects on litter size. However, the combined analyzed results demonstrated that genotype AAAA, ABBB, and BBBB are better than genotype AAAB, AABB, and ABAB for TNB and NBA in either third to eighth parity or all parities. In all parities, the sows with AAAA genotype had an advantage of 1.76 piglets (P < 0.001) for TNB and 1.44 piglets (P < 0.01) for NBA per litter over the AAAB sows, respectively. The results in this study demonstrated that LIF gene was significantly associated with litter size in pigs.
研究了猪白血病抑制因子（LIF）的DNA多态性，并用于研究其对大白猪产仔数的影响。对LIF基因内两个SNP位点（LIF1和LIF2）进行基因分型的420头母猪的2167窝产仔记录进行了分析，以确定LIF是否影响总产仔数（TNB）和产活仔数（NBA）。结果表明，LIF1位点的B等位基因和LIF2位点的A等位基因似乎对产仔数有有利影响。然而，综合分析结果表明，在第三至第八胎或所有胎次中，AAAA、ABBB和BBBB基因型在TNB和NBA方面优于AAAB、AABB和ABAB基因型。在所有胎次中，AAAA基因型的母猪每窝TNB比AAAB基因型的母猪多1.76头仔猪（P<0.001），NBA多1.44头仔猪（P<0.01）。本研究结果表明，LIF基因与猪的产仔数显著相关。
