一种新的大鼠结肠癌细胞系可自发转移：生物学特性及化疗反应
A new rat colon cancer cell line metastasizes spontaneously: biologic characteristics and chemotherapeutic response.
作者信息
Inoue Y, Kashima Y, Aizawa K, Hatakeyama K
机构信息
First Department of Surgery, Niigata University School of Medicine.
出版信息
Jpn J Cancer Res. 1991 Jan;82(1):90-7. doi: 10.1111/j.1349-7006.1991.tb01751.x.
A new cell line (RCN-9) was established in culture from a transplantable rat colon adenocarcinoma, which was induced in the colon of a male Fischer F344 rat by subcutaneous administration of 1,2-dimethylhydrazine. When RCN-9 cells were injected subcutaneously or into the cecal subserosa of syngeneic rats, carcinomas with progressive growth were obtained and the development of lung (63.6%) and liver (40.0%) metastases, respectively, ensued. Antitumor effects of 5-fluorouracil (5-FU), adriamycin (ADM) and mitomycin C (MMC) against RCN-9 were examined in vivo and in vitro. 5-FU and ADM had antitumor effects both in vivo and in vitro; MMC had antitumor effects in vitro. These results show that the RCN-9 cell line can be used both as a model to study mechanisms of metastasis from colon carcinoma and as a model in chemotherapeutic studies of metastatic disease from colon carcinoma.
一种新的细胞系（RCN - 9）是从一只可移植的大鼠结肠腺癌中培养建立的，该腺癌是通过对一只雄性Fischer F344大鼠皮下注射1,2 - 二甲基肼诱导产生于结肠的。当将RCN - 9细胞皮下注射或注入同基因大鼠的盲肠浆膜下层时，可获得进行性生长的癌，并分别出现肺转移（63.6%）和肝转移（40.0%）。在体内和体外研究了5 - 氟尿嘧啶（5 - FU）、阿霉素（ADM）和丝裂霉素C（MMC）对RCN - 9的抗肿瘤作用。5 - FU和ADM在体内和体外均有抗肿瘤作用；MMC在体外有抗肿瘤作用。这些结果表明，RCN - 9细胞系既可以用作研究结肠癌转移机制的模型，也可以用作结肠癌转移性疾病化疗研究的模型。
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