培养新生猪甲状腺组织异种移植治疗大鼠碘 131 后甲状腺功能减退症。
Xenotransplantation of cultured newborn pig thyroid tissue for the treatment of post-radioiodine hypothyroidism in rats.
机构信息
Institute of Endocrinology and Metabolism, Tissue Culture Group, 69 Vyshgorodska Street, 04114, Kyiv, Ukraine,
出版信息
Cytotechnology. 2000 Jul;33(1-3):89-92. doi: 10.1023/A:1008185701106.
The aim of the present study was to develop atransplantation technique for restoration of thyroidfunction in rats with radioiodine-inducedhypothyroidism. Each Wistar rat received the dose of75.0 muCi of 131-iodine by intraperitonealinjection. The serum thyroxine and triiodothyroninevalues in all rats fell to low levels by 2.5 weeksafter radioiodine administration. Thexenotransplantation of 3-day-old newborn pig thyroidorgan culture was performed on day 18 afterradioactive ablation by injection into the fat tissueof anterior abdominal wall. Epithelial cell swarmswith follicular formation manifested themselves amongadipose tissue on day 7 as well as day 17 afterxenotransplantation. The serum thyroxine andtriiodothyronine values in the rats were generallywithin the euthyroid range by day 7-17 afterxenotransplantation. The thyroid gland of ratsreverted to the norm in morphofunctional appearance.These results indicated that the xenografted newbornpig thyroid organ culture allowed a restoration of thyroid function in Wistar rats with post-radioiodine hypothyroidism.
本研究旨在探讨一种通过移植手段来恢复放射性碘诱发的甲状腺功能减退症大鼠甲状腺功能的方法。将每只 Wistar 大鼠经腹腔注射 75.0 μCi 的 131-碘。所有大鼠在放射性碘处理后 2.5 周，血清甲状腺素和三碘甲状腺原氨酸值均降至低水平。放射性消融后 18 天，通过在前腹壁脂肪组织中注射，将 3 日龄新生猪甲状腺器官培养物进行异种移植。异种移植后 7 天和 17 天，在脂肪组织中出现了具有滤泡形成的上皮细胞群。异种移植后 7-17 天，大鼠的血清甲状腺素和三碘甲状腺原氨酸值基本处于正常范围。大鼠的甲状腺在形态和功能上恢复正常。这些结果表明，新生猪甲状腺器官培养物的异种移植可恢复放射性碘后甲状腺功能减退症大鼠的甲状腺功能。
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