用于重建手术的从头脂肪生成。
De novo adipogenesis for reconstructive surgery.
出版信息
Cytotechnology. 1999 Sep;31(1-2):29-35. doi: 10.1023/A:1008055702129.
Autografting of lost soft tissue is an important subject of the plastic and reconstructive surgery and autograft of fat pads has been only technique for this goal. However, the results are disappointing because of absorption of the grafts with time. Adipoblasts or adipocyte precursor cells distribute widely in connective tissues and they can proliferate and mature into adipocytes even in the adult body. In experiments using mice, we found that de novo adipogenesis of endogenous precursor cells can be induced by injecting reconstituted basement membrane, Matrigel, supplemented with more than 1 ng/ml of bFGF. This adipogenesis was reproducibly induced by subcutaneous injection over the chest, lateral abdomen or head. Adipogenesis was induced even in ear cartilage or in muscle. To evaluate the possibility of future application of this de novo adipogenesis to plastic and reconstructive surgery, we have reviewed updated knowledge of the adipogenesis.
自体组织移植是整形和重建外科的一个重要课题，脂肪垫的自体移植一直是达到这一目标的唯一技术。然而，由于移植体随时间吸收，结果并不令人满意。脂肪细胞前体细胞或脂肪母细胞广泛分布于结缔组织中，即使在成年体内，它们也可以增殖并成熟为脂肪细胞。在使用小鼠的实验中，我们发现，通过注射含有超过 1ng/ml bFGF 的重构基底膜 Matrigel，内源性前体细胞的新脂肪生成可以被诱导。这种脂肪生成可以通过胸部、侧腹部或头部的皮下注射重复诱导。即使在耳软骨或肌肉中也能诱导脂肪生成。为了评估这种新脂肪生成术在整形和重建外科中的未来应用的可能性，我们回顾了脂肪生成的最新知识。
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