生物医学和工业相关真菌的蛋白质组学研究。
Proteomic studies in biomedically and industrially relevant fungi.
机构信息
Department of Biology, National Institute for Cellular Biotechnology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
出版信息
Cytotechnology. 2007 Apr;53(1-3):95-100. doi: 10.1007/s10616-007-9054-7. Epub 2007 Feb 17.
Historically, the proteomic investigation of filamentous fungi has been restrained by difficulties associated with efficient protein extraction and the lack of extensive fungal genome sequence databases. The advent of robust protein extraction and separation technologies, combined with protein mass spectrometry and emerging genome sequence data, is leading to the emergence of extensive new knowledge on the nature of these organisms. In this review, we discuss some recent technological advances and their role in exploring the proteome of Aspergillus spp., along with other biotechnologically relevant fungi.
从历史上看，丝状真菌的蛋白质组学研究受到与有效蛋白质提取相关的困难以及缺乏广泛的真菌基因组序列数据库的限制。强大的蛋白质提取和分离技术的出现，结合蛋白质质谱和新兴的基因组序列数据，正在导致这些生物体本质的广泛新知识的出现。在这篇综述中，我们讨论了一些最近的技术进步及其在探索 Aspergillus spp. 及其他具有生物技术相关性的真菌的蛋白质组中的作用。
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