从 Crotalaria sessiliflora 中提取的一种新异黄酮 7,2',4'-三羟基异黄酮-4'-O-β-D-吡喃葡萄糖苷的雌激素和乙酰胆碱酯酶增强活性。
Estrogenic and Acetylcholinesterase-Enhancement Activity of a New Isoflavone, 7,2',4'-Trihydroxyisoflavone-4'-O-beta-D-Glucopyranoside from Crotalaria Sessililflora.
机构信息
Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan.
出版信息
Cytotechnology. 2003 Nov;43(1-3):127-34. doi: 10.1023/b:cyto.0000039899.67160.18.
Abstract
A new isoflavone, 7,2',4'-trihydroxyisoflavone-4'-O-beta-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture. The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).
摘要
一种新的异黄酮，7,2',4'-三羟基异黄酮-4'-O-β-D-吡喃葡萄糖苷，已从平卧马蓝的地上部分中分离得到。该异黄酮糖苷可增强 MCF-7 人乳腺癌细胞系的增殖，该细胞系具有雌激素受体（ER），并在培养中对雌激素有反应。异黄酮糖苷的雌激素性质被已知的 ER 拮抗剂他莫昔芬阻断，表明 ER 的参与。此外，在神经生长因子（NGF）的低浓度下，该异黄酮糖苷被发现可增强大鼠神经元细胞系 PC12 的乙酰胆碱酯酶（AChE）活性。
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Estrogenic and Acetylcholinesterase-Enhancement Activity of a New Isoflavone, 7,2',4'-Trihydroxyisoflavone-4'-O-beta-D-Glucopyranoside from Crotalaria Sessililflora.从 Crotalaria sessiliflora 中提取的一种新异黄酮 7,2',4'-三羟基异黄酮-4'-O-β-D-吡喃葡萄糖苷的雌激素和乙酰胆碱酯酶增强活性。
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