骨髓挽救治疗后体内中性粒细胞形成的群体平衡模型。
Population balance model of in vivo neutrophil formation following bone marrow rescue therapy.
机构信息
Department of Chemical Engineering, The University of, Queensland, Brisbane, QLD 4072, Australia,
出版信息
Cytotechnology. 1998 Nov;28(1-3):157-62. doi: 10.1023/A:1008098118491.
Abstract
In this paper, we develop a simple four parameter population balance model of in vivo neutrophil formation following bone marrow rescue therapy. The model is used to predict the number and type of neutrophil progenitors required to abrogate the period of severe neutropenia that normally follows a bone marrow transplant. The estimated total number of 5 billion neutrophil progenitors is consistent with the value extrapolated from a human trial. The model provides a basis for designing ex vivo expansion protocols.
摘要
在本文中，我们开发了一个简单的四参数群体平衡模型，用于描述骨髓挽救治疗后体内中性粒细胞的形成。该模型用于预测需要多少数量和类型的中性粒细胞祖细胞才能消除骨髓移植后通常出现的严重中性粒细胞减少期。估计的 50 亿个中性粒细胞祖细胞总数与从人体试验中推断出的值一致。该模型为设计体外扩增方案提供了基础。
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