Lavigne Jill E, Griggs Jennifer J, Tu Xin M, Lerner Debra J
Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY 14618, USA.
J Cancer Surviv. 2008 Dec;2(4):296-302. doi: 10.1007/s11764-008-0072-z. Epub 2008 Nov 12.
While fatigue has been associated with work limitations the combined influence of specific diagnosis and treatment exposures based on medical records on work limitations in breast cancer survivors is currently unknown. Since symptom burden and perceived health can interfere with work, the present study investigated the relationship among these variables and work outcomes.
Medical chart abstraction, demographic measures, SF 36, the Work Limitations Questionnaire (WLQ) and measures of symptom burden, including hot flushes were obtained in 83 breast cancer survivors a mean of three years post treatment. OLS and poisson regression were used to determine the relationship of these factors to work productivity and work absences.
Breast cancer survivors reported a mean reduction in productivity of 3.1% below the healthy worker norm. This amounts to a loss of 2.48 hours of work over two weeks of full time employment. Stages 1 and 2 were related to work limitations. After controlling for stage, fatigue and hot flashes were each associated with work performance losses of 1.6% (p = 0.05) and 2.2% (p < 0.001), respectively. Protective factors included marriage and greater personal earned income.
Fatigue and hot flashes are important factors related to work productivity in breast cancer survivors even at three years post treatment. IMPLICATIONS FOR SURVIVORS: Therapy for hot flashes should be given serious consideration in breast cancer survivors who are experiencing work limitations.
虽然疲劳与工作受限有关，但基于医疗记录的特定诊断和治疗暴露对乳腺癌幸存者工作受限的综合影响目前尚不清楚。由于症状负担和感知健康状况可能会影响工作，本研究调查了这些变量与工作结果之间的关系。
在83名乳腺癌幸存者中获取了病历摘要、人口统计学指标、SF-36、工作限制问卷（WLQ）以及包括潮热在内的症状负担测量值，这些幸存者平均在治疗后三年接受调查。使用普通最小二乘法（OLS）和泊松回归来确定这些因素与工作效率和缺勤之间的关系。
乳腺癌幸存者报告称，其工作效率平均比健康工作者标准低3.1%。这相当于在两周的全职工作中损失了2.48小时的工作时间。1期和2期与工作受限有关。在控制分期后，疲劳和潮热分别与1.6%（p = 0.05）和2.2%（p < 0.001）的工作绩效损失相关。保护因素包括婚姻和更高的个人收入。
即使在治疗后三年，疲劳和潮热仍是与乳腺癌幸存者工作效率相关的重要因素。对幸存者的启示：对于经历工作受限的乳腺癌幸存者，应认真考虑潮热的治疗。
