Tanaka Hitoshi, Hattori Hisanori, Oh-Uchi Tomoko, Sato Masaru, Yamaguchi Ryozo, Sako Magoichi, Tateishi Yoichi
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):983-7. doi: 10.1080/10286020802217598.
Two new isoflavanones, 5,3'-dihydroxy-4'-methoxy-5'-(3-methyl-1,3-butadienyl)-2'',2''-dimethylpyrano[5,6:6,7]isoflavanone (1) and 5,3'-dihydroxy-5'-(3-hydroxy-3-methyl-1-butenyl)-4'-methoxy-2'',2''-dimethylpyrano[5,6:6,7]isoflavanone (2), together with two known isoflavonoids, cristacarpin, and euchrenone b10, were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence. These new compounds are rare isoflavanones, possessing both a 2,2-dimethylpyran substituent and a prenyl analog. The antibacterial activities of 1 and 2 against the methicillin-resistant Staphylococcus aureus were examined.
从哥斯达黎加刺桐茎中分离出两种新的异黄酮，5,3'-二羟基-4'-甲氧基-5'-(3-甲基-1,3-丁二烯基)-2'',2''-二甲基吡喃并[5,6:6,7]异黄酮（1）和5,3'-二羟基-5'-(3-羟基-3-甲基-1-丁烯基)-4'-甲氧基-2'',2''-二甲基吡喃并[5,6:6,7]异黄酮（2），以及两种已知的异黄酮类化合物，刺桐定和刺桐酮b10。它们的结构是根据光谱证据确定的。这些新化合物是罕见的异黄酮，同时具有2,2-二甲基吡喃取代基和异戊烯基类似物。检测了1和2对耐甲氧西林金黄色葡萄球菌的抗菌活性。
