来自哥斯达黎加刺桐的三种新异黄酮。

Three new isoflavanones from Erythrina costaricensis.

作者信息

Tanaka Hitoshi, Hattori Hisanori, Oh-Uchi Tomoko, Sato Masaru, Sako Magoichi, Tateishi Yoichi, Rizwani Ghazala Hafeez

机构信息

Faculty of Pharmacy, Meijo University, Nagoya, Japan.

出版信息

Nat Prod Res. 2009;23(12):1089-94. doi: 10.1080/14786410802292286.

DOI:10.1080/14786410802292286

PMID:19662573

Abstract

Three new isoflavanones, 5,7,3'-trihydroxy-4'-methoxy-6,5'-di(gamma, gamma-dimethylallyl)-isoflavanone (1), 5,3'-dihydroxy-4'-methoxy-5'-gamma,gamma-dimethylallyl-2'',2''-dimethylpyrano[5,6 : 6,7]isoflavanone (2) and 5,3'-dihydroxy-2'',2''-dimethylpyrano[5,6 : 6,7]-2''',2'''-dimethylpyrano[5,6 : 5,4]isoflavanone (3), along with two known isoflavonoids, cristacarpin and euchrenone b(10), were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence. Compound 3 is a rare isoflavanone possessing two 2,2-dimethylpyran moieties. Among the new isoflavanones, compound 1 showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus.

摘要

从哥斯达黎加刺桐的茎中分离出三种新的异黄酮，5,7,3'-三羟基-4'-甲氧基-6,5'-二（γ,γ-二甲基烯丙基）异黄酮（1）、5,3'-二羟基-4'-甲氧基-5'-γ,γ-二甲基烯丙基-2'',2''-二甲基吡喃并[5,6 : 6,7]异黄酮（2）和5,3'-二羟基-2'',2''-二甲基吡喃并[5,6 : 6,7]-2''',2'''-二甲基吡喃并[5,6 : 5,4]异黄酮（3），以及两种已知的异黄酮类化合物，刺桐卡品和刺桐酮b(10)。它们的结构是根据光谱证据确定的。化合物3是一种罕见的具有两个2,2-二甲基吡喃部分的异黄酮。在新的异黄酮中，化合物1对耐甲氧西林金黄色葡萄球菌表现出强效抗菌活性。