从夹竹桃科鸡骨常山属植物鸡骨常山根中分离得到的 3 个新化合物及其抗耐甲氧西林金黄色葡萄球菌活性
Three new constituents from the roots of Erythrina variegata and their antibacterial activity against methicillin-resistant Staphylococcus aureus.
机构信息
Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya 468-8503, Japan.
出版信息
Chem Biodivers. 2011 Mar;8(3):476-82. doi: 10.1002/cbdv.201000068.
Two new isoflavonoids, eryvarins V and W (1 and 2, resp.), and a new chromen-4-one derivative, eryvarin X (3), along with three known isoflavonoids, 4-6, were isolated from the roots of Erythrina variegata. Their structures were established by spectroscopic analyses. Compound 1 is a rare naturally occurring isoflavanone which possesses a OH group at C(3). Among the new compounds 1-3, 2 exhibited a potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains.
从夹竹桃科鸡骨常山属植物变色山苦荬（Erythrina variegata）根部分离得到两个新的异黄酮类化合物 eryvarin V 和 W（1 和 2）以及一个新的色满-4-酮衍生物 eryvarin X（3），此外还分离得到三个已知的异黄酮类化合物 4-6。通过光谱分析确定了它们的结构。化合物 1 是一种罕见的天然异黄酮，在 C(3) 位含有一个 OH 基团。在所得到的新化合物 1-3 中，化合物 2 对耐甲氧西林金黄色葡萄球菌（MRSA）菌株表现出很强的抗菌活性。
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