Fumeron F, Brigant L, Parra H J, Bard J M, Fruchart J C, Apfelbaum M
INSERM U286, Faculté X Bichat, Paris, France.
Am J Clin Nutr. 1991 Mar;53(3):655-9. doi: 10.1093/ajcn/53.3.655.
The protective role of high-density lipoproteins (HDLs) has been attributed to the subfractions HDL2 (according to the density) and lipoprotein A-I (LpA-I) (according to the composition in apolipoproteins). We investigated the effect of a high ratio of polyunsaturated to saturated fatty acids (P:S) on these subfractions in a homogeneous group of young adult males. Two prescribed diets were consumed successively at the subjects' homes for 3 wk each in a random order; one diet contained 70 g butter (P:S 0.2, diet B), the other contained 70 g sunflower margarine (P:S 1.1, diet M). Total calorie, fat, and cholesterol intakes were similar for the two diets. Cholesterol and apolipoprotein B in serum and in low-density lipoproteins (LDLs) were lower with diet M than with diet B. However, significant decreases in protective subfractions of HDL, HDL2, and LpA-I were observed. This undesirable effect of the diet with a high P:S could cancel the benefits of lowering the LDL-cholesterol concentrations.
高密度脂蛋白（HDL）的保护作用归因于HDL2亚组分（根据密度）和载脂蛋白A-I（LpA-I）亚组分（根据载脂蛋白组成）。我们在一组同质的年轻成年男性中研究了高比例的多不饱和脂肪酸与饱和脂肪酸（P:S）对这些亚组分的影响。两种规定饮食在受试者家中依次食用，每种饮食随机食用3周；一种饮食含有70克黄油（P:S 0.2，饮食B），另一种饮食含有70克向日葵人造黄油（P:S 1.1，饮食M）。两种饮食的总热量、脂肪和胆固醇摄入量相似。与饮食B相比，饮食M使血清和低密度脂蛋白（LDL）中的胆固醇和载脂蛋白B降低。然而，观察到HDL、HDL2和LpA-I的保护性亚组分显著降低。这种高P:S饮食的不良影响可能会抵消降低LDL胆固醇浓度带来的益处。
