Tizard E J, Baguley E, Hughes G R, Dillon M J
Department of Paediatric Nephrology, Sick Children, London.
Arch Dis Child. 1991 Feb;66(2):189-92. doi: 10.1136/adc.66.2.189.
Kawasaki disease is an acute vasculitic illness of childhood associated with significant morbidity and mortality. A cellular based enzyme linked immunosorbent assay (ELISA) was used to demonstrate the presence of antiendothelial cell antibodies in sera from children with Kawasaki disease. Twenty one of 32 patients with Kawasaki disease had raised IgM antibody titres and four had raised IgG antiendothelial antibody titres. There was a significant difference in the IgM antiendothelial cell antibody titres when comparing the patients with normals and febrile controls. The antibody titre paralleled the disease activity in patients studied serially. There was no relative increase in binding of antiendothelial cell antibodies after cytokine stimulation. These findings may be of importance in further research into the understanding of mechanisms involved in this and other forms of vasculitis in man.
川崎病是一种儿童期急性血管炎性疾病，可导致显著的发病率和死亡率。采用基于细胞的酶联免疫吸附测定（ELISA）法来检测川崎病患儿血清中抗内皮细胞抗体的存在情况。32例川崎病患者中，21例IgM抗体滴度升高，4例IgG抗内皮细胞抗体滴度升高。与正常人和发热对照者相比，川崎病患者的IgM抗内皮细胞抗体滴度存在显著差异。在连续研究的患者中，抗体滴度与疾病活动度平行。细胞因子刺激后抗内皮细胞抗体的结合没有相对增加。这些发现对于进一步了解人类这种及其他形式血管炎的发病机制可能具有重要意义。
