在川崎病中通过基于细胞的酶联免疫吸附测定法检测到的抗内皮细胞抗体。
Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease.
作者信息
Tizard E J, Baguley E, Hughes G R, Dillon M J
机构信息
Department of Paediatric Nephrology, Sick Children, London.
出版信息
Arch Dis Child. 1991 Feb;66(2):189-92. doi: 10.1136/adc.66.2.189.
Abstract
Kawasaki disease is an acute vasculitic illness of childhood associated with significant morbidity and mortality. A cellular based enzyme linked immunosorbent assay (ELISA) was used to demonstrate the presence of antiendothelial cell antibodies in sera from children with Kawasaki disease. Twenty one of 32 patients with Kawasaki disease had raised IgM antibody titres and four had raised IgG antiendothelial antibody titres. There was a significant difference in the IgM antiendothelial cell antibody titres when comparing the patients with normals and febrile controls. The antibody titre paralleled the disease activity in patients studied serially. There was no relative increase in binding of antiendothelial cell antibodies after cytokine stimulation. These findings may be of importance in further research into the understanding of mechanisms involved in this and other forms of vasculitis in man.
摘要
川崎病是一种儿童期急性血管炎性疾病，可导致显著的发病率和死亡率。采用基于细胞的酶联免疫吸附测定（ELISA）法来检测川崎病患儿血清中抗内皮细胞抗体的存在情况。32例川崎病患者中，21例IgM抗体滴度升高，4例IgG抗内皮细胞抗体滴度升高。与正常人和发热对照者相比，川崎病患者的IgM抗内皮细胞抗体滴度存在显著差异。在连续研究的患者中，抗体滴度与疾病活动度平行。细胞因子刺激后抗内皮细胞抗体的结合没有相对增加。这些发现对于进一步了解人类这种及其他形式血管炎的发病机制可能具有重要意义。
相似文献
1
Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease.在川崎病中通过基于细胞的酶联免疫吸附测定法检测到的抗内皮细胞抗体。
Arch Dis Child. 1991 Feb;66(2):189-92. doi: 10.1136/adc.66.2.189.
2
Antiendothelial cell antibodies can be cytotoxic to endothelial cells without cytokine pre-stimulation and correlate with ELISA antibody measurement in Kawasaki disease.抗内皮细胞抗体在无细胞因子预刺激的情况下可对内皮细胞产生细胞毒性，且与川崎病中的酶联免疫吸附测定抗体检测结果相关。
Clin Exp Immunol. 1994 Nov;98(2):264-9. doi: 10.1111/j.1365-2249.1994.tb06136.x.
3
Antibodies to endothelial cells in Kawasaki disease lyse endothelial cells without cytokine pretreatment.川崎病中针对内皮细胞的抗体在无细胞因子预处理的情况下可溶解内皮细胞。
Clin Exp Immunol. 1997 Jan;107(1):120-6. doi: 10.1046/j.1365-2249.1997.d01-894.x.
4
Antineutrophil cytoplasm antibodies in Kawasaki disease.川崎病中的抗中性粒细胞胞浆抗体
Arch Dis Child. 1989 Mar;64(3):360-3. doi: 10.1136/adc.64.3.360.
5
Elevated IgA and IgM anticardiolipin antibodies in acute Kawasaki disease.急性川崎病中IgA和IgM抗心磷脂抗体升高。
Cardiology. 2002;97(4):180-2. doi: 10.1159/000063118.
6
Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies are not increased in Kawasaki disease.川崎病中抗中性粒细胞胞浆抗体和抗内皮细胞抗体并未增加。
Br J Rheumatol. 1995 Sep;34(9):882-7. doi: 10.1093/rheumatology/34.9.882.
7
Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease.川崎病患者血清中抗金黄色葡萄球菌和化脓性链球菌超抗原IgM抗体的产生情况
Clin Exp Immunol. 2006 Mar;143(3):427-34. doi: 10.1111/j.1365-2249.2006.03015.x.
8
Cryoprecipitates in Kawasaki syndrome: association with coronary artery aneurysms.川崎病中的冷沉淀：与冠状动脉瘤的关联。
Pediatr Infect Dis J. 1988 Apr;7(4):255-7. doi: 10.1097/00006454-198804000-00004.
9
Cytopathogenic protein in filtrates from cultures of Propionibacterium acnes isolated from patients with Kawasaki disease.从川崎病患者分离出的痤疮丙酸杆菌培养滤液中的细胞致病蛋白。
Br Med J (Clin Res Ed). 1987 Nov 14;295(6608):1229-32. doi: 10.1136/bmj.295.6608.1229.
10
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.川崎病急性期存在的免疫球蛋白M抗体可溶解由γ干扰素刺激培养的血管内皮细胞。
J Clin Invest. 1986 May;77(5):1428-35. doi: 10.1172/JCI112454.
引用本文的文献
1
How Should We Classify Kawasaki Disease?我们应该如何分类川崎病？
Front Immunol. 2018 Dec 14;9:2974. doi: 10.3389/fimmu.2018.02974. eCollection 2018.
2
Noninvasive determination of endothelial cell function in the microcirculation in Kawasaki syndrome.川崎病微血管内皮细胞功能的无创测定
Pediatr Cardiol. 2008 Jan;29(1):121-5. doi: 10.1007/s00246-007-9077-z. Epub 2007 Sep 21.
3
Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India.印度北部一组儿童川崎病急性期后自身抗体谱的研究。
Rheumatol Int. 2006 Jun;26(8):693-6. doi: 10.1007/s00296-005-0050-y. Epub 2005 Nov 25.
4
The level of IgA antibodies to human umbilical vein endothelial cells can be enhanced by TNF-alpha treatment in children with Henoch-Schönlein purpura.在过敏性紫癜患儿中，肿瘤坏死因子-α治疗可提高其针对人脐静脉内皮细胞的IgA抗体水平。
Clin Exp Immunol. 2002 Nov;130(2):352-7. doi: 10.1046/j.1365-2249.2002.01964.x.
5
Intravenous immunoglobulin in neurological disease: a specialist review.静脉注射免疫球蛋白在神经系统疾病中的应用：专家综述
J Neurol Neurosurg Psychiatry. 2002 Apr;72(4):440-8. doi: 10.1136/jnnp.72.4.440.
6
Sera from patients with systemic lupus erythematosus demonstrate enhanced IgG binding to endothelial cells pretreated with tumour necrosis factor alpha.系统性红斑狼疮患者的血清显示，其IgG与经肿瘤坏死因子α预处理的内皮细胞的结合增强。
Rheumatol Int. 1995;15(3):99-105. doi: 10.1007/BF00302125.
7
Serum immunoglobulin G reactive with endothelial cells in inflammatory bowel disease.炎症性肠病中与内皮细胞反应的血清免疫球蛋白G
Dig Dis Sci. 1994 Sep;39(9):1909-17. doi: 10.1007/BF02088124.
8
Antiendothelial cell antibodies can be cytotoxic to endothelial cells without cytokine pre-stimulation and correlate with ELISA antibody measurement in Kawasaki disease.抗内皮细胞抗体在无细胞因子预刺激的情况下可对内皮细胞产生细胞毒性，且与川崎病中的酶联免疫吸附测定抗体检测结果相关。
Clin Exp Immunol. 1994 Nov;98(2):264-9. doi: 10.1111/j.1365-2249.1994.tb06136.x.
9
Anti-endothelial cell antibodies and autoimmune diseases.抗内皮细胞抗体与自身免疫性疾病。
Clin Rev Allergy. 1994 Fall;12(3):275-86. doi: 10.1007/BF02802322.
10
Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies.抗中性粒细胞胞浆抗体和抗内皮细胞抗体。
Pediatr Nephrol. 1991 Mar;5(2):256-9. doi: 10.1007/BF01095967.
本文引用的文献
1
Immunoregulatory abnormalities in mucocutaneous lymph node syndrome.皮肤黏膜淋巴结综合征中的免疫调节异常。
Clin Immunol Immunopathol. 1982 Apr;23(1):100-12. doi: 10.1016/0090-1229(82)90075-7.
2
High-dose intravenous gammaglobulin for Kawasaki disease.大剂量静脉注射丙种球蛋白治疗川崎病。
Lancet. 1984 Nov 10;2(8411):1055-8. doi: 10.1016/s0140-6736(84)91504-6.
3
4
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.源自脐静脉的人内皮细胞培养。通过形态学和免疫学标准进行鉴定。
J Clin Invest. 1973 Nov;52(11):2745-56. doi: 10.1172/JCI107470.
5
Nationwide survey on Kawasaki disease in Japan.日本全国川崎病调查。
Pediatrics. 1987 Jul;80(1):58-62.
6
Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome.两种单核因子，即白细胞介素-1和肿瘤坏死因子，可使培养的血管内皮细胞易被川崎病期间循环的抗体溶解。
J Exp Med. 1986 Dec 1;164(6):1958-72. doi: 10.1084/jem.164.6.1958.
7
Kawasaki syndrome.川崎病
Rev Infect Dis. 1988 Jan-Feb;10(1):1-15. doi: 10.1093/clinids/10.1.1.
8
Kawasaki disease: cardiac problems and management.川崎病：心脏问题与管理
Pediatr Rev. 1988 Jan;9(7):209-17. doi: 10.1542/pir.9-7-209.
9
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.川崎病急性期存在的免疫球蛋白M抗体可溶解由γ干扰素刺激培养的血管内皮细胞。
J Clin Invest. 1986 May;77(5):1428-35. doi: 10.1172/JCI112454.
10
Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease.内皮细胞活化及高白细胞介素-1分泌在急性川崎病发病机制中的作用
Lancet. 1989 Dec 2;2(8675):1298-302. doi: 10.1016/s0140-6736(89)91910-7.
Zotero 插件